{"id":"W2900077869","doi":"10.1016/j.jaci.2018.10.033","title":"Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council","year":2018,"lang":"en","type":"review","venue":"Journal of Allergy and Clinical Immunology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"H2020 European Research Council; NIHR Newcastle Biomedical Research Centre; Engineering and Physical Sciences Research Council; Chugai Pharmaceutical; Genentech; LEO Pharma; H. Lundbeck A/S; Beiersdorf; Almirall; Galderma; Astellas Pharma; Mount Sylvia Diatomite; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; AbbVie; Glenmark Pharmaceuticals; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Dermira; Bristol-Myers Squibb; Royal Society; Janssen Biotech; Medical Research Council; Medical Research Council Canada; Les Laboratories Pierre Fabre; British Association of Dermatologists; Wellcome Trust; National Institutes of Health; Regeneron Pharmaceuticals; Newcastle University; Kiniksa Pharmaceuticals; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Kyowa Hakko Kirin; Sanofi; Celgene; Novartis; GlaxoSmithKline; British Skin Foundation; Allergan; AstraZeneca; Lundbeckfonden; Eli Lilly and Company; Amgen; Pfizer; Dermatology Foundation","keywords":"Atopic dermatitis; Dermatology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004870287,0.0001623561,0.00157031,0.00005041052,0.00005442257,0.000006243516,0.0002039954,0.000284721,0.00007131945],"category_scores_gemma":[0.0003608985,0.00009909228,0.0002892568,0.00004231148,0.001175346,0.00009813676,0.0001139909,0.0003948982,3.422031e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002858633,"about_ca_system_score_gemma":0.0004351194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006533997,"about_ca_topic_score_gemma":0.000006338383,"domain_scores_codex":[0.9978777,0.0003583755,0.001293642,0.0001710174,0.0002125251,0.00008672955],"domain_scores_gemma":[0.9976487,0.0003414297,0.001176947,0.0001571384,0.0006027023,0.00007310502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008814696,0.009454794,0.004185337,0.04906486,0.0824392,0.0003634086,0.005220141,0.000004205888,0.0000143968,0.01653603,0.2132965,0.6185396],"study_design_scores_gemma":[0.005086095,0.002112294,0.02457576,0.05230971,0.005438954,0.01134217,0.0007855195,0.00008384093,0.000001505681,0.007763205,0.8900685,0.0004324363],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004391551,0.9940129,0.00001849843,0.001064312,0.0001514504,0.0001471882,0.00002053585,0.000002330351,0.000191234],"genre_scores_gemma":[0.004824732,0.9942459,0.0001314852,0.0006227198,0.00007624758,0.000003274738,0.00001027645,0.000008995648,0.00007634682],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.676772,"threshold_uncertainty_score":0.4330612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1590819198340429,"score_gpt":0.4016575420233192,"score_spread":0.2425756221892764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}