{"id":"W2900081406","doi":"10.1182/blood-2018-99-110623","title":"A Phase 3 Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adults with Paroxysmal Nocturnal Hemoglobinuria Naive to Complement Inhibitors: Results of a Subgroup Analysis with Patients Stratified By Baseline Hemolysis Level, Transfusion History, and Demographics","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Eculizumab; Paroxysmal nocturnal hemoglobinuria; Medicine; Clinical endpoint; Internal medicine; Surrogate endpoint; Hemoglobinuria; Pediatrics; Hemolysis; Immunology; Clinical trial; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003555895,0.0003615346,0.000834741,0.0006064327,0.000106667,0.000009152898,0.000247175,0.0001025655,0.0001377254],"category_scores_gemma":[0.00005756854,0.0002906645,0.0001055782,0.0009668509,0.000274921,0.00008685684,0.00007492308,0.0001489581,0.000001614433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001008484,"about_ca_system_score_gemma":0.0001144651,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002509003,"about_ca_topic_score_gemma":0.02186761,"domain_scores_codex":[0.9971171,0.000484189,0.001079258,0.0006889091,0.0002630373,0.0003675136],"domain_scores_gemma":[0.9982631,0.0001767609,0.0005376208,0.0005045887,0.0004286555,0.00008928665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.204813,0.05756031,0.6691095,0.0003872108,0.01012132,0.00004621319,0.02564324,0.00003793451,0.02756554,0.00001327108,0.002714431,0.00198797],"study_design_scores_gemma":[0.6168042,0.1235109,0.172635,0.0011409,0.009798598,0.00001959879,0.01931545,0.00009681132,0.05456135,0.00000232472,0.0007701638,0.001344681],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961096,0.0003911956,0.0001645635,0.00002983516,0.0001019063,0.001659169,0.001487697,0.00002088963,0.00003514707],"genre_scores_gemma":[0.9988547,0.000009500071,0.0002386256,0.00001262227,0.00001799564,0.00008393993,0.0007509277,0.00002033801,0.00001133736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4964746,"threshold_uncertainty_score":0.9999545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717227513868953,"score_gpt":0.2509781351508674,"score_spread":0.2338058600121778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}