{"id":"W2900081406","doi":"10.1182/blood-2018-99-110623","title":"A Phase 3 Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adults with Paroxysmal Nocturnal Hemoglobinuria Naive to Complement Inhibitors: Results of a Subgroup Analysis with Patients Stratified By Baseline Hemolysis Level, Transfusion History, and Demographics","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Eculizumab; Paroxysmal nocturnal hemoglobinuria; Medicine; Clinical endpoint; Internal medicine; Surrogate endpoint; Hemoglobinuria; Pediatrics; Hemolysis; Immunology; Clinical trial; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004409196,0.001586536,0.003417408,0.0004447001,0.0004929296,0.001164104,0.0008194618,0.001272031,0.003049958],"category_scores_gemma":[0.003114462,0.000686383,0.005710007,0.0003984895,0.0007891415,0.001246735,0.0004769419,0.002683228,0.0005121112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007920438,"about_ca_system_score_gemma":0.001295035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005002987,"about_ca_topic_score_gemma":0.001269742,"domain_scores_codex":[0.9982355,0.0009878977,0.0001411769,0.0002802564,0.0001340656,0.0002210613],"domain_scores_gemma":[0.9981218,0.0004976198,0.0004678233,0.0002899818,0.0001371484,0.0004855585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9530739,0.01074067,0.00719784,0.000340572,0.007224936,0.0000958637,0.0001422182,0.0004555706,0.005306291,0.00008902613,0.0005673535,0.0147658],"study_design_scores_gemma":[0.5866141,0.3635358,0.03827108,0.00005807359,0.006686162,0.0002361197,0.0001474247,0.001534825,0.001380198,0.0003252618,0.001140742,0.00007026135],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944448,0.002036859,0.0005353865,0.0002189299,0.0001414151,0.00156507,0.0004909786,0.0000350226,0.0005315594],"genre_scores_gemma":[0.9942333,0.000712235,0.001081949,0.0005381338,0.0001853915,0.00168557,0.0009089647,0.00001468684,0.0006397278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004409196,"threshold_uncertainty_score":0.02331835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717227513868953,"score_gpt":0.2509781351508674,"score_spread":0.2338058600121778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}