{"id":"W2900093343","doi":"10.1182/blood-2018-99-110805","title":"The Medalist Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Myelodysplastic syndromes; Anemia; Clinical endpoint; Internal medicine; Erythropoiesis; International Prognostic Scoring System; Placebo; Ineffective erythropoiesis; Randomized controlled trial; Gastroenterology; Surgery; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001137671,0.000584582,0.002313685,0.0004937203,0.0002376807,0.00004224183,0.0003255114,0.0002624756,0.00004198107],"category_scores_gemma":[0.0007322888,0.000292512,0.0002326654,0.0008759529,0.0005079095,0.0001534026,0.00008122843,0.0004724391,0.000005586466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004934516,"about_ca_system_score_gemma":0.0003239677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006993026,"about_ca_topic_score_gemma":0.002840227,"domain_scores_codex":[0.9953235,0.0005678399,0.001886081,0.0007257767,0.0008542233,0.0006425419],"domain_scores_gemma":[0.996375,0.001240393,0.0008081162,0.0008518841,0.0003993917,0.0003252428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9683352,0.01705446,0.001882623,0.0003309619,0.001114442,0.0001911299,0.0100675,0.0001688464,0.0005781857,0.000001123583,0.00002514272,0.0002503909],"study_design_scores_gemma":[0.9508201,0.03388967,0.0005813561,0.002119107,0.004849162,0.00002126506,0.003526388,0.0001211211,0.003727171,0.000002345538,0.000003383861,0.0003388595],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98605,0.00007701449,0.00002169554,0.00009782217,0.0001786685,0.01289651,0.00007781231,0.00006071845,0.000539761],"genre_scores_gemma":[0.9985824,0.0002028094,0.00005838811,0.00002210066,0.00007137315,0.0005920394,0.00003200343,0.00009176778,0.0003470813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01751502,"threshold_uncertainty_score":0.9999527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006538640406576,"score_gpt":0.2538856776182557,"score_spread":0.2438202912141899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}