{"id":"W2900093343","doi":"10.1182/blood-2018-99-110805","title":"The Medalist Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Myelodysplastic syndromes; Anemia; Clinical endpoint; Internal medicine; Erythropoiesis; International Prognostic Scoring System; Placebo; Ineffective erythropoiesis; Randomized controlled trial; Gastroenterology; Surgery; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001861405,0.001677488,0.002394509,0.0003409796,0.0004165459,0.001115021,0.0008114351,0.001644176,0.00725595],"category_scores_gemma":[0.001601675,0.0004456424,0.002029451,0.000308108,0.0009766072,0.0009601575,0.0003516015,0.002563117,0.001088748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005620913,"about_ca_system_score_gemma":0.0007928413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003652342,"about_ca_topic_score_gemma":0.001201657,"domain_scores_codex":[0.999567,0.0002243342,0.00003164988,0.00007607784,0.0000457354,0.00005517558],"domain_scores_gemma":[0.9993817,0.000151731,0.0001861792,0.00005003405,0.00005246409,0.0001779201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9596642,0.005565684,0.0008505894,0.002155866,0.002384341,0.00009007182,0.00007297996,0.0003398319,0.005219544,0.0003050355,0.003736207,0.01961567],"study_design_scores_gemma":[0.9732944,0.02268659,0.001554018,0.00005522504,0.0006319223,0.00005561192,0.00001350144,0.0002099222,0.0002991437,0.0001595733,0.001026456,0.00001375607],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9467278,0.02225734,0.001648945,0.003089177,0.001459976,0.009067383,0.006427196,0.0003913043,0.008930931],"genre_scores_gemma":[0.962871,0.007161723,0.003085368,0.004746142,0.0009325608,0.008765283,0.005248843,0.0000661548,0.00712304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00725595,"threshold_uncertainty_score":0.02427351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006538640406576,"score_gpt":0.2538856776182557,"score_spread":0.2438202912141899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}