{"id":"W2900097455","doi":"10.1164/rccm.201808-1493oc","title":"The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial","year":2018,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Obstructive Sleep Apnea Research","field":"Medicine","cited_by":280,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; Università degli Studi di Brescia; National Health and Medical Research Council; Menzies Foundation; American Thoracic Society; National Center for Research Resources; Medical Research Council; American Heart Association","keywords":"Medicine; Placebo; Oxybutynin; Anesthesia; Polysomnography; Obstructive sleep apnea; Crossover study; Interquartile range; Sleep apnea; Randomized controlled trial; Atomoxetine; Continuous positive airway pressure; Apnea; Internal medicine; Overactive bladder; Attention deficit hyperactivity disorder","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001582103,0.00127022,0.004034583,0.0005601824,0.0006542375,0.0007496418,0.0009569793,0.00202297,0.006398086],"category_scores_gemma":[0.001920626,0.0009673357,0.001600186,0.0005125703,0.0009796466,0.0008493371,0.0003491176,0.001620278,0.0008240532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005661276,"about_ca_system_score_gemma":0.0008728555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001380628,"about_ca_topic_score_gemma":0.002530728,"domain_scores_codex":[0.9989008,0.0005440573,0.0001345494,0.0002003138,0.0001023391,0.0001179978],"domain_scores_gemma":[0.9990215,0.0002966632,0.0002302233,0.00007603953,0.0001055407,0.000270067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9862213,0.004119777,0.0002498391,0.0005766352,0.0008448897,0.00001817435,0.0000209806,0.00004584325,0.001746935,0.00003151779,0.0003006407,0.005823485],"study_design_scores_gemma":[0.9704273,0.02788919,0.0009174204,0.00001637739,0.0003402135,0.000009574776,0.000009572594,0.0001024154,0.0001306311,0.00002401353,0.0001271127,0.000006190111],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815144,0.006302026,0.0008042029,0.0005918487,0.00117998,0.006567256,0.001086497,0.0001830495,0.001770744],"genre_scores_gemma":[0.9806066,0.003938713,0.002276592,0.0009763378,0.0009718203,0.007950096,0.0008616253,0.00002268376,0.002395614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006398086,"threshold_uncertainty_score":0.02140373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496935482280267,"score_gpt":0.3510134833500696,"score_spread":0.3260441285272669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}