{"id":"W2900118139","doi":"10.1007/s12035-018-1412-2","title":"A Novel Mecp2Y120D Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome","year":2018,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"College of Family Physicians of Canada","funders":"Fondazione Telethon","keywords":"Rett syndrome; MECP2; Chromatin; Phenotype; Biology; Neuroscience; Mutation; Genetics; Knockout mouse; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001887612,0.0004282,0.0004489889,0.0001019807,0.0001930259,0.00001770335,0.0006529287,0.0001914709,0.000007162885],"category_scores_gemma":[0.00009332212,0.0002706928,0.0002157701,0.000208789,0.0003258014,0.000003482626,0.0002037804,0.0001032811,0.000002247903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000305824,"about_ca_system_score_gemma":0.00006775968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009310668,"about_ca_topic_score_gemma":0.0004856643,"domain_scores_codex":[0.9978315,0.0001361813,0.000503079,0.0008005268,0.0001790927,0.000549624],"domain_scores_gemma":[0.9988226,0.00007188568,0.0001546327,0.0007029671,0.000133841,0.0001140392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004037729,0.0003089527,0.00008128904,0.00001085179,0.00007022636,0.00001256878,0.0002819677,0.005354853,0.9917101,0.00006246912,0.000620178,0.001082789],"study_design_scores_gemma":[0.003808397,0.007624102,0.01477334,0.00003827901,0.0002229565,0.0001760027,0.0001721751,0.004369092,0.9594266,0.0001555146,0.008630674,0.0006028311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676445,0.0005548822,0.02822901,0.001410704,0.0002062612,0.001637852,0.0002437333,0.00001280789,0.00006031753],"genre_scores_gemma":[0.9965442,0.0001182921,0.001481287,0.001059372,0.00003030651,0.0003039383,0.000206364,0.00006968591,0.0001865286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03228344,"threshold_uncertainty_score":0.9999745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02620532838136411,"score_gpt":0.2916069813343417,"score_spread":0.2654016529529775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}