{"id":"W2900138717","doi":"10.1093/neuonc/noy148.125","title":"CBMT-06. LOWER GRADE ISOCITRATE DEHYDROGENASE (IDH) MUTANT GLIOMAS METABOLICALLY MIMICKING GLIOBLASTOMA (GBM) EXPRESS HIGHER R:S 2-HYDROXYGLUTARATE RATIOS RELATIVE TO NON-GBM-MIMICKING IDH MUTANT GLIOMAS","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto Western Hospital; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Isocitrate dehydrogenase; IDH1; Glioma; Cancer research; Mutant; Wild type; Carcinogenesis; Metabolic pathway; Biology; Chemistry; Metabolism; Internal medicine; Medicine; Enzyme; Cancer; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490207,0.000313516,0.0003867353,0.0003947003,0.0002674841,0.0003260218,0.0002916171,0.0003380595,0.002245313],"category_scores_gemma":[0.0002279639,0.0001279484,0.000188342,0.0004181221,0.0002371104,0.0001665106,0.000157676,0.0007143036,0.0006280144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004474031,"about_ca_system_score_gemma":0.0005376201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003908017,"about_ca_topic_score_gemma":0.005422053,"domain_scores_codex":[0.9998237,0.00001710614,0.00001322755,0.00004161514,0.00006437075,0.00003992155],"domain_scores_gemma":[0.9998668,0.00001303373,0.00002502834,0.00001631201,0.000018477,0.00006028435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001944179,0.0005316375,0.005799687,0.00009658322,0.00003229341,0.0002389393,0.00003062959,0.0002574209,0.9800686,0.0001830764,0.001020127,0.009796829],"study_design_scores_gemma":[0.0003159635,0.005369924,0.07228509,0.00002301105,0.00009235297,0.003074629,0.00007659683,0.002345928,0.9019566,0.000225323,0.01421305,0.00002152233],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914103,0.000968621,0.001046105,0.0001984933,0.00005505329,0.0001249196,0.003064055,0.0002689571,0.002863491],"genre_scores_gemma":[0.9845599,0.0005330297,0.002431571,0.0001848371,0.00001133861,0.0001599048,0.008357874,0.00004660663,0.003714876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003908017,"threshold_uncertainty_score":0.007770538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479315168443126,"score_gpt":0.2784057015416299,"score_spread":0.2636125498571987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}