{"id":"W2900166117","doi":"","title":"Lipid encapsulation promotes co-localization of methylated CpG ODN and TLR9 in late endosomes: A new model for the immunostimulatory activity of CpG DNA","year":2008,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada); University of British Columbia","funders":"","keywords":"TLR9; CpG Oligodeoxynucleotide; CpG site; Toll-Like Receptor 9; DNA methylation; Immune system; Methylation; Innate immune system; Cell biology; Biology; Chemistry; DNA; Cancer research; Molecular biology; Immunology; Biochemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550687,0.0003042273,0.0002027697,0.0001163498,0.0001505788,0.0003363178,0.000246104,0.0003825006,0.0008259427],"category_scores_gemma":[0.0001091693,0.0001555749,0.0002896067,0.00009335526,0.0002181559,0.000369472,0.0003707346,0.0004392923,0.0003811609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004627261,"about_ca_system_score_gemma":0.0001737755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006319691,"about_ca_topic_score_gemma":0.000713074,"domain_scores_codex":[0.9998986,0.0000155975,0.000005879655,0.00002449538,0.00002686087,0.0000287154],"domain_scores_gemma":[0.9999423,0.00001128516,0.00002162271,0.000007023843,0.000007731226,0.00001004735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005591814,0.00001743522,0.00004456639,0.00002385742,0.000002309598,0.00003993812,0.00001208721,0.00008017384,0.9987595,0.000301613,0.00002046449,0.0006420891],"study_design_scores_gemma":[0.000008080234,0.000117448,0.0002311238,0.000002560211,0.000004919219,0.00005104898,0.000007220021,0.001239089,0.9970289,0.00003763247,0.001268893,0.000003208577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788716,0.001079166,0.01633451,0.0002208866,0.00005641465,0.00006592937,0.0001128228,0.00009681863,0.003161809],"genre_scores_gemma":[0.9864036,0.0005769154,0.008805937,0.00006088907,0.00001017445,0.0000474791,0.000104484,0.00003618636,0.003954219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008259427,"threshold_uncertainty_score":0.003357351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09721256468504698,"score_gpt":0.3786951196497882,"score_spread":0.2814825549647412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}