{"id":"W2900192395","doi":"10.1093/neuonc/noy148.168","title":"CSIG-02. VAL-083 INHIBITS PROLIFERATION OF A PANEL OF EIGHT GLIOBLASTOMA STEM CELL LINES: DOWNREGULATION OF BDR4 AS A NOVEL ANTI-NEOPLASTIC MECHANISM","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"","keywords":"Neurosphere; Cancer research; Stem cell; OLIG2; Cell growth; Downregulation and upregulation; Biology; Cyclin D1; Stem cell marker; Nestin; Cell cycle; Chemistry; Neural stem cell; Cell biology; Cellular differentiation; Cell; Oligodendrocyte; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030799,0.0003054016,0.0003206019,0.0002065703,0.0001289368,0.0002605971,0.0002754829,0.0002393343,0.001418108],"category_scores_gemma":[0.00006789852,0.0001023615,0.0002733224,0.0003005441,0.0001926387,0.00008632396,0.0001284707,0.0006470167,0.0004374405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000336564,"about_ca_system_score_gemma":0.0003914433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0015847,"about_ca_topic_score_gemma":0.003260075,"domain_scores_codex":[0.9999214,0.00001196297,0.000007740136,0.00001287224,0.0000253801,0.00002052957],"domain_scores_gemma":[0.9999639,0.000004515749,0.000006576896,0.000005158524,0.000005316698,0.00001448318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005990182,0.000268202,0.0005333823,0.00007253726,0.00002095344,0.00006314256,0.00002592851,0.0002508831,0.9907363,0.00008253205,0.000408585,0.006938608],"study_design_scores_gemma":[0.0002377362,0.003204907,0.01076577,0.000007382054,0.00005898588,0.0004972427,0.0000423308,0.001532401,0.9781348,0.00004596718,0.0054628,0.000009696932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955388,0.0008996288,0.0005022919,0.0001253319,0.00002140809,0.00004544916,0.0009480771,0.0001123164,0.001806723],"genre_scores_gemma":[0.9933816,0.0006581018,0.001396188,0.0001116858,0.000004922209,0.00006525785,0.002651544,0.0000168926,0.001713741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015847,"threshold_uncertainty_score":0.004744053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570420584508861,"score_gpt":0.2522941678922644,"score_spread":0.2365899620471758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}