{"id":"W2900213158","doi":"10.1182/blood-2018-99-119147","title":"Results from a Phase 3, Multicenter, Non-Inferiority Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Currently Treated with Eculizumab","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Eculizumab; Paroxysmal nocturnal hemoglobinuria; Medicine; Hemoglobinuria; Internal medicine; Dosing; Gastroenterology; Anemia; Immunology; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000123315,0.0005515508,0.0008281437,0.0002247766,0.0001927198,0.00003574317,0.0005230648,0.0001742834,0.000286994],"category_scores_gemma":[0.0001469521,0.0004218716,0.00009724795,0.0004172559,0.000316494,0.0002041007,0.0001746787,0.0003142325,0.00009830968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287363,"about_ca_system_score_gemma":0.0001800722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00429857,"about_ca_topic_score_gemma":0.004230801,"domain_scores_codex":[0.996718,0.0004333908,0.001033519,0.0009116075,0.0002454544,0.0006579694],"domain_scores_gemma":[0.9975616,0.0002000634,0.0006536128,0.000907424,0.0005787399,0.00009852519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1762925,0.05609544,0.7524667,0.00008100396,0.002621627,0.0001553679,0.006191084,0.000008849677,0.003781728,0.000006201519,0.0005144555,0.00178506],"study_design_scores_gemma":[0.5709041,0.02401348,0.3796634,0.0005540411,0.001157008,0.00001222818,0.002533626,0.00003588016,0.02008731,0.000002356203,0.0003121601,0.0007243526],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948175,0.0001222892,0.00001357162,0.0000128569,0.0005164061,0.002104178,0.002024909,0.00008358821,0.0003047069],"genre_scores_gemma":[0.9983722,0.000004117062,0.0001065634,0.00001248793,0.00007501862,0.0001092701,0.001251817,0.00004297402,0.00002556948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3946117,"threshold_uncertainty_score":0.9998233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262623858297723,"score_gpt":0.2637900671497698,"score_spread":0.2511638285667926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}