{"id":"W2900213158","doi":"10.1182/blood-2018-99-119147","title":"Results from a Phase 3, Multicenter, Non-Inferiority Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Currently Treated with Eculizumab","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Eculizumab; Paroxysmal nocturnal hemoglobinuria; Medicine; Hemoglobinuria; Internal medicine; Dosing; Gastroenterology; Anemia; Immunology; Antibody; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00683124,0.001051106,0.002334095,0.0003041907,0.000467418,0.00119109,0.0007791696,0.001118446,0.003396761],"category_scores_gemma":[0.002736873,0.0005100017,0.002587487,0.0003559897,0.0008472351,0.001110129,0.0003345502,0.002640375,0.0005324292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008453312,"about_ca_system_score_gemma":0.001348413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004036118,"about_ca_topic_score_gemma":0.001188756,"domain_scores_codex":[0.9975485,0.001647023,0.0001844516,0.0002412766,0.0001880521,0.0001906886],"domain_scores_gemma":[0.9979064,0.0005817409,0.0006007301,0.0002023428,0.0001582186,0.0005505779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8852339,0.03033633,0.00722256,0.0007387687,0.004051933,0.0001535609,0.0002357849,0.0008854022,0.01942646,0.0002480664,0.001590585,0.04987663],"study_design_scores_gemma":[0.5675918,0.3974377,0.02705966,0.00006397399,0.002359393,0.0002341752,0.00007996344,0.001050902,0.002300331,0.0002368032,0.001544999,0.0000403142],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913098,0.003864035,0.0007026237,0.0004065259,0.0001414162,0.001817079,0.0006346581,0.00004182704,0.001082081],"genre_scores_gemma":[0.9942151,0.001022548,0.001152876,0.0006592503,0.0001615576,0.001409289,0.0007266184,0.00001226853,0.000640608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00683124,"threshold_uncertainty_score":0.03612751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262623858297723,"score_gpt":0.2637900671497698,"score_spread":0.2511638285667926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}