{"id":"W2900266255","doi":"10.1074/jbc.ra118.005352","title":"Coagulation factor XIIIa cross-links amyloid β into dimers and oligomers and to blood proteins","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Canadian Institutes of Health Research; Ministry of Technology, Innovation and Citizens' Services; Canada Foundation for Innovation; Centre for Blood Research, University of British Columbia; University of British Columbia; National Institutes of Health; Government of Canada; Michael Smith Health Research BC","keywords":"Factor XIIIa; Cerebral amyloid angiopathy; Fibrin; Chemistry; Amyloid (mycology); Factor XIII; Tissue transglutaminase; Platelet; Biochemistry; Antithrombin; Coagulation; Pathology; Fibrinogen; Immunology; Medicine; Internal medicine; Heparin; Enzyme; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380678,0.0001056249,0.0002325921,0.00002231962,0.00007661933,0.00003099894,0.00004706803,0.0002499187,0.0001187229],"category_scores_gemma":[0.0001831865,0.00006519908,0.00004729425,0.00006784327,0.0001960712,0.00005561531,0.00004730967,0.0002479838,0.000002001368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001955459,"about_ca_system_score_gemma":0.00002936504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000832215,"about_ca_topic_score_gemma":3.372113e-7,"domain_scores_codex":[0.9992913,0.00001325367,0.0002882656,0.0001440414,0.0001340368,0.0001290766],"domain_scores_gemma":[0.9993847,0.00002248308,0.0001432955,0.00007795074,0.0001859324,0.0001856091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000453735,0.00006310175,0.07084864,0.00005762424,0.00005927219,0.000008246532,0.0002203972,7.947388e-7,0.9188762,0.000002112777,0.00002146612,0.009388389],"study_design_scores_gemma":[0.001361788,0.001557942,0.3899803,0.0001132241,0.0000748005,0.000316638,0.0001265158,0.00003917658,0.60445,0.0001319003,0.001715091,0.0001326801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980948,0.0006752997,0.00006943919,0.0007805409,0.00004065798,0.0001164462,0.00000212952,0.00001056237,0.0002101362],"genre_scores_gemma":[0.9980776,0.00007971921,0.001037603,0.0003069848,0.0003738748,0.00000209779,0.00000263572,0.000006015378,0.000113495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3191316,"threshold_uncertainty_score":0.2658741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0266071472883432,"score_gpt":0.2892819591023452,"score_spread":0.262674811814002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}