{"id":"W2900303949","doi":"10.1093/neuonc/noy148.019","title":"ATIM-24. INTERIM RESULTS OF A PHASE II MULTICENTER STUDY OF THE CONDITIONALLY REPLICATIVE ONCOLYTIC ADENOVIRUS DNX-2401 WITH PEMBROLIZUMAB (KEYTRUDA) FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"","keywords":"Oncolytic virus; Pembrolizumab; Interim; Medicine; Oncolytic adenovirus; Glioblastoma; Oncology; Internal medicine; Phases of clinical research; Virology; Cancer research; Clinical trial; Cancer; Immunotherapy; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003897728,0.00201482,0.001426879,0.0004783381,0.0007021821,0.001565327,0.001627202,0.002015119,0.009125125],"category_scores_gemma":[0.001546268,0.0008100998,0.001195792,0.0003710721,0.0005318555,0.0008770295,0.0004913126,0.003366325,0.003111531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001135604,"about_ca_system_score_gemma":0.001849595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053902,"about_ca_topic_score_gemma":0.002228487,"domain_scores_codex":[0.9993499,0.0002921914,0.00002908981,0.00009140425,0.00008591828,0.0001516011],"domain_scores_gemma":[0.9990238,0.0001166689,0.0001890037,0.00010625,0.00007494102,0.0004893965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4586673,0.05414322,0.01464391,0.001335494,0.00323216,0.001203221,0.0004733197,0.00557776,0.09841144,0.001995177,0.102788,0.257529],"study_design_scores_gemma":[0.473549,0.3920383,0.03304885,0.0001077973,0.001745081,0.00139927,0.00007676656,0.002529104,0.01990631,0.001322479,0.07418922,0.00008777306],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8700786,0.01269896,0.007342579,0.004316262,0.001970106,0.0160606,0.04444106,0.001661846,0.04143],"genre_scores_gemma":[0.8639504,0.004553851,0.01165468,0.004955589,0.001019803,0.01587695,0.06774284,0.0003986721,0.02984708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009125125,"threshold_uncertainty_score":0.03052652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04237353089257623,"score_gpt":0.3679382324752952,"score_spread":0.3255647015827189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}