{"id":"W2900303949","doi":"10.1093/neuonc/noy148.019","title":"ATIM-24. INTERIM RESULTS OF A PHASE II MULTICENTER STUDY OF THE CONDITIONALLY REPLICATIVE ONCOLYTIC ADENOVIRUS DNX-2401 WITH PEMBROLIZUMAB (KEYTRUDA) FOR RECURRENT GLIOBLASTOMA; CAPTIVE STUDY (KEYNOTE-192)","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"","keywords":"Oncolytic virus; Pembrolizumab; Interim; Medicine; Oncolytic adenovirus; Glioblastoma; Oncology; Internal medicine; Phases of clinical research; Virology; Cancer research; Clinical trial; Cancer; Immunotherapy; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003503953,0.0003707458,0.001009608,0.0002335669,0.0002198179,0.000009001273,0.0003189879,0.000119988,0.00006060058],"category_scores_gemma":[0.001059771,0.0002209856,0.0001880208,0.0004275061,0.0005304561,0.00007108239,0.0002754138,0.0003003168,0.000009579469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004732903,"about_ca_system_score_gemma":0.0005795473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001224601,"about_ca_topic_score_gemma":0.001858925,"domain_scores_codex":[0.9967502,0.0004521921,0.0009981802,0.0008349916,0.0005533979,0.0004110233],"domain_scores_gemma":[0.995612,0.001115578,0.001059812,0.0009641685,0.001036316,0.0002121121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3618378,0.3318242,0.02024207,0.0002193839,0.004681133,0.0006778113,0.1007772,0.00003918417,0.1381202,0.0001753393,0.01448075,0.02692492],"study_design_scores_gemma":[0.1651219,0.7033049,0.03048246,0.0002709714,0.0022724,0.0001176494,0.0127882,0.0003869912,0.07815958,0.00003023169,0.006769445,0.0002952112],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887798,0.00003010167,0.00001893702,0.001492844,0.0004549887,0.008266472,0.0003925719,0.00003635956,0.0005278536],"genre_scores_gemma":[0.997708,0.000005819779,0.000182897,0.0004080386,0.0001673207,0.001414777,0.00002516586,0.00004971487,0.00003830046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3714807,"threshold_uncertainty_score":0.901153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04237353089257623,"score_gpt":0.3679382324752952,"score_spread":0.3255647015827189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}