{"id":"W2900342617","doi":"10.1093/neuonc/noy148.313","title":"DRES-06. PREVENTING THE EMERGENCE OF TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA BY PARP-1 INHIBITION","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Temozolomide; MSH6; Cancer research; Biology; PARP inhibitor; DNA repair; Synthetic lethality; MSH2; Methyltransferase; Poly ADP ribose polymerase; MLH1; DNA mismatch repair; Molecular biology; Gene; Genetics; Methylation; Polymerase; Glioblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660915,0.0004073917,0.000491828,0.000371901,0.0001332561,0.0002728704,0.000387268,0.0003268951,0.003043802],"category_scores_gemma":[0.0001105782,0.0001471189,0.0003418648,0.0002742237,0.0001560496,0.0001357626,0.0001423094,0.0009611844,0.001005802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002457532,"about_ca_system_score_gemma":0.0002904515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007589108,"about_ca_topic_score_gemma":0.001815451,"domain_scores_codex":[0.9999112,0.00001337492,0.000009224776,0.00001665044,0.00001788461,0.00003177227],"domain_scores_gemma":[0.9999477,0.000004961657,0.00001206363,0.000006579186,0.000007112032,0.00002157631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002019,0.001226373,0.0007208212,0.0003341426,0.00006161525,0.0002770684,0.00004333571,0.0007053789,0.9532844,0.0006038931,0.002151987,0.03857198],"study_design_scores_gemma":[0.001091736,0.01368033,0.01298694,0.00005781521,0.00012782,0.001641609,0.00006418961,0.00304086,0.94318,0.0002289019,0.02386609,0.00003374548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793465,0.006647812,0.002557213,0.000445281,0.000161433,0.0001915223,0.002255155,0.0008680546,0.007527059],"genre_scores_gemma":[0.983274,0.003480084,0.002842812,0.0002479006,0.00002083655,0.0001192012,0.004187573,0.00004045057,0.005787029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003043802,"threshold_uncertainty_score":0.0101825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949112033093168,"score_gpt":0.3336514222823488,"score_spread":0.3141603019514171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}