{"id":"W2900364017","doi":"10.1016/j.kint.2018.08.025","title":"A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis","year":2018,"lang":"en","type":"article","venue":"Kidney International","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":304,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Medicine; Placebo; Lupus nephritis; Clinical endpoint; Adverse effect; Dose-ranging study; Internal medicine; Calcineurin; Randomized controlled trial; Gastroenterology; Multicenter trial; Urology; Transplantation; Double blind; Multicenter study; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002852065,0.001580032,0.005773126,0.000875117,0.0008626974,0.001095708,0.001612344,0.003052809,0.005698194],"category_scores_gemma":[0.004131025,0.001133735,0.00208409,0.0007582851,0.002867117,0.001716663,0.0006506965,0.003768639,0.0007178451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008090325,"about_ca_system_score_gemma":0.001561263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406026,"about_ca_topic_score_gemma":0.001780442,"domain_scores_codex":[0.9981883,0.0009516696,0.0002179778,0.0003173921,0.0001406318,0.0001839644],"domain_scores_gemma":[0.9963413,0.001646818,0.0006135827,0.0003964012,0.0002263381,0.0007755233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9892172,0.004964231,0.0001273708,0.000293691,0.0003546685,0.00001400313,0.00002117497,0.00007379403,0.001062996,0.00003723528,0.0001020803,0.003731662],"study_design_scores_gemma":[0.9598424,0.03916666,0.0004034182,0.000009139573,0.0001951836,0.000008278149,0.000006976187,0.00009503974,0.0001514423,0.00003156142,0.00008362237,0.00000628059],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877528,0.003709936,0.001150145,0.0004144412,0.0007066475,0.004149005,0.0006816773,0.0001634482,0.001271949],"genre_scores_gemma":[0.9869423,0.002537097,0.00254659,0.0009560586,0.0008633514,0.003902529,0.0007131914,0.00003267053,0.001506229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005773126,"threshold_uncertainty_score":0.0190624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044650872840483,"score_gpt":0.3059892698606966,"score_spread":0.2855427611322918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}