{"id":"W2900391822","doi":"10.2147/dddt.s138765","title":"CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia","year":2018,"lang":"en","type":"review","venue":"Drug Design Development and Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Cytokine release syndrome; Chimeric antigen receptor; Context (archaeology); Medicine; Oncology; Internal medicine; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003046627,0.0005444229,0.0007411767,0.002014415,0.0002215608,0.0004881691,0.0005689201,0.000622267,0.002565349],"category_scores_gemma":[0.0003666361,0.0001582857,0.0003231156,0.001556037,0.000279229,0.0007257316,0.0004498503,0.001420501,0.001759022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003449367,"about_ca_system_score_gemma":0.0005334413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006869108,"about_ca_topic_score_gemma":0.0012229,"domain_scores_codex":[0.9998771,0.00001995955,0.00002139248,0.0000234093,0.00004758376,0.00001064643],"domain_scores_gemma":[0.9998848,0.00004908066,0.00002363574,0.000003433803,0.00002593326,0.00001308857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000657866,0.00006072086,0.00008092352,0.009007316,0.00005142875,0.0001404218,0.00003813806,0.0002456303,0.001512319,0.00191736,0.02149943,0.9653806],"study_design_scores_gemma":[0.00002645664,0.0001256816,0.0005263524,0.00199026,0.00007740385,0.001869619,0.0000317361,0.00007751118,0.00067216,0.0007363782,0.9938549,0.00001146064],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002179487,0.9982305,0.0001158337,0.000168964,0.0001357989,0.000005981772,0.00001709619,0.0000101332,0.001097836],"genre_scores_gemma":[0.001364272,0.9972721,0.0001690154,0.0002158356,0.0001044162,0.000009082476,0.00003719265,0.000001828378,0.0008263268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002565349,"threshold_uncertainty_score":0.008581936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06862769789823206,"score_gpt":0.3288503921926857,"score_spread":0.2602226942944537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}