{"id":"W2900406456","doi":"10.1016/j.molcel.2018.09.031","title":"MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":213,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Natural Sciences and Engineering Research Council of Canada; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Wellcome Trust; Mount Sylvia Diatomite; Ontario Genomics Institute; Canada Foundation for Innovation; Genome Canada; AbbVie; Merck KGaA; Boehringer Ingelheim; Pfizer","keywords":"Biology; Interactome; Transcription factor; Carcinogenesis; Genetics; Histone; Cell biology; Acetylation; Enhancer; DNA-binding protein; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001062863,0.0003056346,0.0002241929,0.0004192748,0.0002414767,0.0004103043,0.0002247331,0.0003340107,0.00154215],"category_scores_gemma":[0.0001836607,0.000181044,0.0003368415,0.000285623,0.0002156852,0.0002388178,0.0002464233,0.0003989162,0.0006728009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003188435,"about_ca_system_score_gemma":0.0001398393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005195012,"about_ca_topic_score_gemma":0.001270274,"domain_scores_codex":[0.999848,0.00001468833,0.00001125672,0.00004376155,0.00004406824,0.00003826473],"domain_scores_gemma":[0.9998075,0.00003628871,0.00006221998,0.00002690427,0.00001826646,0.00004880364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009135668,0.000007238762,0.0004045505,0.000007295696,0.000005058297,0.00004181306,0.000003674771,0.0000414684,0.9988441,0.0001019018,0.00002002021,0.0004314438],"study_design_scores_gemma":[0.000008931516,0.00007209275,0.01827331,0.000002141388,0.00002508604,0.0006740027,0.00001990195,0.001283424,0.9782416,0.0001145108,0.001280648,0.000004363808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924483,0.0005523351,0.004749647,0.0000658356,0.00001141664,0.00001114424,0.0008397673,0.00009025035,0.001231412],"genre_scores_gemma":[0.9959404,0.000148094,0.00202635,0.0000448012,0.000004633454,0.000009692903,0.0008384623,0.00004100738,0.0009464252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154215,"threshold_uncertainty_score":0.00515902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549218782419058,"score_gpt":0.2436471312747791,"score_spread":0.2281549434505885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}