{"id":"W2900406456","doi":"10.1016/j.molcel.2018.09.031","title":"MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":213,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Natural Sciences and Engineering Research Council of Canada; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Wellcome Trust; Mount Sylvia Diatomite; Ontario Genomics Institute; Canada Foundation for Innovation; Genome Canada; AbbVie; Merck KGaA; Boehringer Ingelheim; Pfizer","keywords":"Biology; Interactome; Transcription factor; Carcinogenesis; Genetics; Histone; Cell biology; Acetylation; Enhancer; DNA-binding protein; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002363178,0.0002781341,0.000197543,0.00007814635,0.0001910953,0.00006916015,0.0003138916,0.0001448743,0.0001253664],"category_scores_gemma":[0.0001188913,0.0002671342,0.0001359251,0.0002017544,0.00007728222,0.000006454441,0.0002401428,0.0001280536,0.000365295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002986884,"about_ca_system_score_gemma":0.0001175361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001235497,"about_ca_topic_score_gemma":0.00001692821,"domain_scores_codex":[0.9983073,0.0001443486,0.0002477887,0.0006476303,0.000226107,0.0004268321],"domain_scores_gemma":[0.9988049,0.000008798838,0.0001039583,0.0005749514,0.0002801183,0.0002272577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084435,0.0000677066,0.0006575451,0.00003273194,0.00003259879,0.00002514392,0.00006184994,0.000009174083,0.9972589,0.0002879167,0.001169422,0.0002885553],"study_design_scores_gemma":[0.0003133015,0.0006127598,0.0004684285,0.00004851703,0.0000189176,0.00001173862,0.00004272432,0.00002101017,0.9601183,0.0001422135,0.03785281,0.0003493112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655175,0.0002127016,0.02106588,0.0002849902,0.0002223056,0.0009550558,0.00005319235,0.00004507081,0.01164333],"genre_scores_gemma":[0.9879649,0.000005721158,0.004041992,0.001113781,0.0003955239,0.0002606028,0.0002118953,0.00006301354,0.005942531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03714064,"threshold_uncertainty_score":0.9999781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549218782419058,"score_gpt":0.2436471312747791,"score_spread":0.2281549434505885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}