{"id":"W2900449902","doi":"10.1038/s41386-018-0277-4","title":"VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine","year":2018,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université Laval","funders":"National Center for Complementary and Integrative Health; National Institutes of Health; Hope for Depression Research Foundation; National Institute of Mental Health; BrightFocus Foundation","keywords":"Prefrontal cortex; Psychology; Ventromedial prefrontal cortex; Neuroscience; Depression (economics); Ketamine; Terminal (telecommunication); Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003379052,0.0002376428,0.0002731254,0.0002177878,0.0002088325,0.00003887123,0.0003268927,0.0001111278,0.0002528255],"category_scores_gemma":[0.0004484264,0.0001828848,0.0000437178,0.0003778786,0.0007954437,0.0001264192,0.0002309393,0.0003706256,0.00008224323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000211361,"about_ca_system_score_gemma":0.00003473215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008428729,"about_ca_topic_score_gemma":0.0000200197,"domain_scores_codex":[0.9972697,0.000967714,0.0003524388,0.0007359475,0.0002066051,0.0004675932],"domain_scores_gemma":[0.9987867,0.000639477,0.0001098046,0.0002172974,0.00002788383,0.0002188537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01223921,0.0001211815,0.0006021217,0.000005600396,0.000004637084,0.0003352644,0.001039548,0.000001647731,0.9825827,0.00004016749,0.0005620324,0.002465818],"study_design_scores_gemma":[0.01322666,0.000806288,0.9512639,0.00002223409,0.00003703056,0.0005851429,0.00003618388,0.0006539953,0.03026029,0.0001519371,0.002693185,0.0002631618],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952118,0.0001505775,0.000001368418,0.00197114,0.0013692,0.0008287015,0.00001475526,0.00006179179,0.0003907032],"genre_scores_gemma":[0.995226,0.00009469881,0.0000129958,0.003435713,0.0001246511,0.00007244093,9.987234e-7,0.0000333304,0.0009992283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9523225,"threshold_uncertainty_score":0.7457828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183904136343455,"score_gpt":0.2952249570872306,"score_spread":0.2833859157237961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}