{"id":"W2900541213","doi":"10.1002/cbic.201800579","title":"Improved Efficacy of Antibody Cancer Immunotherapeutics through Local and Sustained Delivery","year":2018,"lang":"en","type":"review","venue":"ChemBioChem","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Antibody; Immunotherapy; Immune system; Cancer; Cancer research; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000352033,0.0005386802,0.001520058,0.000076671,0.00009220615,0.00006482937,0.0005537008,0.0004125303,0.0002147541],"category_scores_gemma":[0.00006425787,0.0004533446,0.0003031215,0.0003432785,0.0008376988,0.0001450649,0.0003025565,0.0002133089,0.00006372134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000215466,"about_ca_system_score_gemma":0.0006946136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001728778,"about_ca_topic_score_gemma":0.000003909435,"domain_scores_codex":[0.9975162,0.0001087635,0.0008370869,0.0007186352,0.0002690819,0.0005502804],"domain_scores_gemma":[0.997932,0.0002694427,0.0006101565,0.0008081939,0.000277874,0.0001023377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001894987,0.0004194182,0.000002878813,0.0255447,0.0003427293,0.00001751954,0.0004310724,8.641455e-7,0.6672974,0.00009929313,0.0007030019,0.3049517],"study_design_scores_gemma":[0.0007978788,0.0001117691,8.529791e-7,0.003765115,0.000736126,0.00001213284,0.0000680739,0.00003416933,0.8190391,0.00001583817,0.174914,0.0005048734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04862321,0.9498172,0.0002219758,0.00001506633,0.0003773897,0.0006678322,0.0001218684,0.00008036663,0.00007511163],"genre_scores_gemma":[0.009586314,0.9892036,0.0004963386,0.00007198197,0.0002176692,0.00005369149,0.00006006292,0.00009788248,0.0002124512],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3044468,"threshold_uncertainty_score":0.9997918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298103194635536,"score_gpt":0.3310233050378288,"score_spread":0.3012129855742752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}