{"id":"W2900541213","doi":"10.1002/cbic.201800579","title":"Improved Efficacy of Antibody Cancer Immunotherapeutics through Local and Sustained Delivery","year":2018,"lang":"en","type":"review","venue":"ChemBioChem","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; McMaster University","keywords":"Antibody; Immunotherapy; Immune system; Cancer; Cancer research; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003560256,0.0006269977,0.000669981,0.001376519,0.0001905435,0.0006240197,0.0004901133,0.0007356885,0.002081275],"category_scores_gemma":[0.0002911002,0.0002335619,0.000319203,0.001008263,0.0002709435,0.0008198055,0.0004298163,0.001066932,0.001123419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000492233,"about_ca_system_score_gemma":0.0005612136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004924405,"about_ca_topic_score_gemma":0.000766123,"domain_scores_codex":[0.9998643,0.00001672315,0.00001254002,0.0000237981,0.00006584446,0.00001681257],"domain_scores_gemma":[0.9999117,0.00003103465,0.00001780898,0.000003584685,0.00002941958,0.000006450359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006141244,0.00009426209,0.0001150815,0.019453,0.00006530309,0.0002601858,0.00007927662,0.000676954,0.03285085,0.01199959,0.01675843,0.9175857],"study_design_scores_gemma":[0.00001237082,0.000134186,0.0005829805,0.001437905,0.00006435563,0.001315858,0.00003856298,0.0002720278,0.0125707,0.001404792,0.9821472,0.0000192352],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000862066,0.9955385,0.0006132635,0.0001937231,0.0001675115,0.000008596219,0.00001842523,0.00001370886,0.002584223],"genre_scores_gemma":[0.004706061,0.9925176,0.0005799736,0.0001212966,0.00009551476,0.00001283416,0.00002586755,0.000003301734,0.001937554],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002081275,"threshold_uncertainty_score":0.006962538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298103194635536,"score_gpt":0.3310233050378288,"score_spread":0.3012129855742752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}