{"id":"W2900570413","doi":"10.1161/circulationaha.117.026229","title":"Composite End Points in Clinical Research","year":2017,"lang":"en","type":"review","venue":"Circulation","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre","funders":"","keywords":"Medicine; Clinical trial; Event (particle physics); Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.03710869,0.0002960312,0.003173616,0.0003476936,0.0001578546,0.0001301541,0.0007448466,0.001091354,0.000235643],"category_scores_gemma":[0.2641907,0.0002545044,0.0006512513,0.0002987039,0.0004072511,0.00007440551,0.0002664542,0.002008235,0.0005579255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002398705,"about_ca_system_score_gemma":0.0003033782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001014352,"about_ca_topic_score_gemma":0.000008679367,"domain_scores_codex":[0.9843764,0.01035656,0.003249813,0.0007912235,0.0007826805,0.0004432672],"domain_scores_gemma":[0.8643634,0.1327374,0.001075924,0.001468838,0.0002007967,0.0001535929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000007253768,0.0001322034,0.0004738921,0.005691406,0.0000534819,0.00002797559,0.00001051052,5.597561e-8,3.265885e-8,0.02292044,0.0003201283,0.9703626],"study_design_scores_gemma":[0.0003513963,0.00001978958,0.002329904,0.01201477,0.0002252741,0.000004657511,0.000001414313,0.00003680255,5.514562e-8,0.6895347,0.2952524,0.0002288642],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003765018,0.9834691,0.005403234,0.00005663956,0.001697284,0.00249117,0.00007407144,0.00006634302,0.006704537],"genre_scores_gemma":[0.00006357869,0.8740342,0.1246346,0.00001036178,0.0009765567,0.0001004873,0.0000232379,0.00007628104,0.00008063426],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9701338,"threshold_uncertainty_score":0.9999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9668561325273701,"score_gpt":0.7787165620159249,"score_spread":0.1881395705114453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}