{"id":"W2900586920","doi":"10.1093/ije/dyy244","title":"Mendelian randomization analysis of C-reactive protein on colorectal cancer risk","year":2018,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Cancer Care Ontario; Public Health Ontario; University of Toronto","funders":"Maine Community College System; Niilo Helanderin Säätiö; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Cancer Council Victoria; Instituto de Salud Carlos III; American Association for Cancer Research; Medical Engineering Centre, King’s College London; Intramural Research Program; Presbyterian Historical Society; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Conseil Régional des Pays de la Loire; Vetenskapsrådet; Ligue Contre le Cancer; Swedish Cancer Foundation; Memorial Sloan-Kettering Cancer Center; National Engineering College; Federación Española de Enfermedades Raras; Canadian Institutes of Health Research; National Human Genome Research Institute; Mechanics Electronics Computer Corporation; Damon Runyon Cancer Research Foundation; Women's Health Initiative; AstraZeneca; National Health and Medical Research Council; Cancer Research UK; American Cancer Society; Canadian Cancer Society Research Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Odds ratio; Medicine; Colorectal cancer; Confounding; Single-nucleotide polymorphism; Internal medicine; Oncology; Confidence interval; Cancer; Genotype; Genetics; Biology; Genetic variants; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05256781,0.00164933,0.002882458,0.002581287,0.0007478241,0.001167826,0.001848891,0.001838044,0.007203548],"category_scores_gemma":[0.1241195,0.0007272963,0.003822431,0.002624199,0.001614411,0.000992389,0.001152733,0.001215596,0.0006988182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129559,"about_ca_system_score_gemma":0.001817353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003740337,"about_ca_topic_score_gemma":0.001400378,"domain_scores_codex":[0.9009573,0.08577836,0.001320889,0.006912432,0.003814009,0.00121715],"domain_scores_gemma":[0.8963038,0.08338456,0.006933308,0.01093864,0.001788832,0.0006507283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07372309,0.001328174,0.3890882,0.002412993,0.04069569,0.006974825,0.001580488,0.07614356,0.01168546,0.1378476,0.01214075,0.2463792],"study_design_scores_gemma":[0.01254561,0.009588423,0.1536988,0.0004128863,0.01488245,0.006092315,0.0002501045,0.679986,0.004425715,0.1064209,0.0113089,0.0003879255],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4978233,0.002952632,0.4879474,0.000967259,0.000556751,0.002373986,0.002063289,0.001614369,0.003700958],"genre_scores_gemma":[0.8804123,0.0006092807,0.1131232,0.0003504488,0.0001132608,0.002610516,0.0007683439,0.0001778091,0.001834743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05256781,"threshold_uncertainty_score":0.2780085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02707588258125624,"score_gpt":0.3663839453116958,"score_spread":0.3393080627304396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}