{"id":"W2900586920","doi":"10.1093/ije/dyy244","title":"Mendelian randomization analysis of C-reactive protein on colorectal cancer risk","year":2018,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Cancer Care Ontario; Public Health Ontario; University of Toronto","funders":"Maine Community College System; Niilo Helanderin Säätiö; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Cancer Council Victoria; Instituto de Salud Carlos III; American Association for Cancer Research; Medical Engineering Centre, King’s College London; Intramural Research Program; Presbyterian Historical Society; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Conseil Régional des Pays de la Loire; Vetenskapsrådet; Ligue Contre le Cancer; Swedish Cancer Foundation; Memorial Sloan-Kettering Cancer Center; National Engineering College; Federación Española de Enfermedades Raras; Canadian Institutes of Health Research; National Human Genome Research Institute; Mechanics Electronics Computer Corporation; Damon Runyon Cancer Research Foundation; Women's Health Initiative; AstraZeneca; National Health and Medical Research Council; Cancer Research UK; American Cancer Society; Canadian Cancer Society Research Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Odds ratio; Medicine; Colorectal cancer; Confounding; Single-nucleotide polymorphism; Internal medicine; Oncology; Confidence interval; Cancer; Genotype; Genetics; Biology; Genetic variants; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001341584,0.0001014203,0.0006910542,0.000710034,0.00002684155,0.000002824042,0.0001451745,0.00008909428,0.0005256269],"category_scores_gemma":[0.007487858,0.00007206877,0.0003445237,0.0002570388,0.0001861048,0.0000935014,0.00001381265,0.0001709128,0.000005711345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001925,"about_ca_system_score_gemma":0.000184813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002407516,"about_ca_topic_score_gemma":0.0000593751,"domain_scores_codex":[0.9981566,0.0004056627,0.0009101084,0.0001299296,0.0002718115,0.0001258929],"domain_scores_gemma":[0.9957737,0.0007810136,0.001533162,0.00009051702,0.001728089,0.00009352282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03455934,0.0007109664,0.8370271,0.00002435769,0.03132745,0.00007795382,0.00110001,0.006977969,0.02240667,0.009304654,0.007308352,0.04917513],"study_design_scores_gemma":[0.01031327,0.001347975,0.9242886,0.0002409535,0.005893606,0.00009640623,0.0001161151,0.009237086,0.02346313,0.004221393,0.02059864,0.000182782],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846125,0.000219669,0.006472062,0.00716113,0.0005342513,0.0001701813,0.00006471232,0.000006754967,0.0007587317],"genre_scores_gemma":[0.9945941,0.0001626237,0.00114302,0.002438044,0.001514738,0.00001155988,0.00003981566,0.000007561264,0.00008854078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0872615,"threshold_uncertainty_score":0.8964206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02707588258125624,"score_gpt":0.3663839453116958,"score_spread":0.3393080627304396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}