{"id":"W2900594433","doi":"10.1007/s00221-018-5434-9","title":"5-HT2A blockade for dyskinesia and psychosis in Parkinson’s disease: is there a limit to the efficacy of this approach? A study in the MPTP-lesioned marmoset and a literature mini-review","year":2018,"lang":"en","type":"review","venue":"Experimental Brain Research","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Université de Montréal; McGill University; Montreal Neurological Institute and Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Parkinson Canada; Weston Brain Institute; Michael J. Fox Foundation for Parkinson's Research","keywords":"Dyskinesia; MPTP; Parkinsonism; Psychosis; Parkinson's disease; Marmoset; Blockade; Medicine; Levodopa; Psychology; Anesthesia; Internal medicine; Pharmacology; Disease; Psychiatry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007621218,0.0006768304,0.00246261,0.001671341,0.0001943973,0.0009409873,0.001088301,0.001011286,0.004706167],"category_scores_gemma":[0.001007802,0.0002876897,0.0008980976,0.001555598,0.0003980098,0.0009379922,0.0005000677,0.001739527,0.001145442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00039054,"about_ca_system_score_gemma":0.001187919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00141688,"about_ca_topic_score_gemma":0.004211045,"domain_scores_codex":[0.9998242,0.00003316066,0.0000495766,0.00002715087,0.00005233622,0.00001354844],"domain_scores_gemma":[0.9994174,0.0003849152,0.00008616172,0.00001142883,0.0000752421,0.00002486861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002061598,0.00008518899,0.0001086838,0.08964315,0.0004562794,0.0002070797,0.00006830182,0.0002417477,0.001233632,0.002217826,0.01698025,0.8885517],"study_design_scores_gemma":[0.000166211,0.0003753106,0.001620553,0.03973677,0.001820755,0.001844736,0.0001622019,0.0001239901,0.0006855908,0.002363771,0.9510494,0.00005066732],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006724751,0.9995097,0.00002722895,0.0001151996,0.00006255128,0.000003897825,0.00001707184,0.000001943859,0.0001951117],"genre_scores_gemma":[0.0004461051,0.999141,0.00009232147,0.0001257618,0.00004735703,0.000004464402,0.00001482911,5.778239e-7,0.000127641],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004706167,"threshold_uncertainty_score":0.01574373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1308783081021334,"score_gpt":0.4614662747323388,"score_spread":0.3305879666302054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}