{"id":"W2900595715","doi":"10.1371/journal.ppat.1007398","title":"HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université du Québec à Trois-Rivières","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Mitacs","keywords":"Cytotoxic T cell; Viral replication; Capsid; Tetherin; Innate immune system; Viremia; Cytosol; Biology; Virology; Virus; Cell biology; Immune system; In vitro; Immunology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103201,0.0002754758,0.0001664462,0.0002097011,0.0001706636,0.0003586212,0.0001459403,0.0001979604,0.002210668],"category_scores_gemma":[0.00008942494,0.00009361422,0.0002004478,0.00009434001,0.0001334554,0.0001784895,0.0002330247,0.0005097479,0.000372897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001573474,"about_ca_system_score_gemma":0.00008236573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003771285,"about_ca_topic_score_gemma":0.000346509,"domain_scores_codex":[0.9999009,0.00001315425,0.000008442888,0.00002810611,0.00002004386,0.00002928032],"domain_scores_gemma":[0.9999313,0.000008124318,0.00002100989,0.00001120722,0.00000739181,0.00002091509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009742216,0.00002755205,0.0008924976,0.00001970672,0.000009548833,0.00006514785,0.00001838712,0.00001907678,0.9970672,0.00007704163,0.00003741827,0.00166908],"study_design_scores_gemma":[0.00005293941,0.0009560735,0.03399534,0.00001995725,0.00006172945,0.002428303,0.0001896934,0.001110664,0.9569968,0.0002018768,0.003975198,0.00001140845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984182,0.0002596935,0.0007464108,0.0000197515,0.000005099203,0.000008993958,0.0001081406,0.00001458747,0.0004190484],"genre_scores_gemma":[0.9972373,0.0002077119,0.0007702925,0.00003238484,0.000005606563,0.00001374518,0.0004722602,0.00001366917,0.001247008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210668,"threshold_uncertainty_score":0.007395446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758332784544402,"score_gpt":0.2480992418893185,"score_spread":0.2305159140438745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}