{"id":"W2900595715","doi":"10.1371/journal.ppat.1007398","title":"HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université du Québec à Trois-Rivières","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Mitacs","keywords":"Cytotoxic T cell; Viral replication; Capsid; Tetherin; Innate immune system; Viremia; Cytosol; Biology; Virology; Virus; Cell biology; Immune system; In vitro; Immunology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002090295,0.0002011204,0.0003669135,0.0001107077,0.0002828226,0.00002121786,0.0002330818,0.000125702,0.0003343736],"category_scores_gemma":[0.000128771,0.0001403323,0.00009291954,0.000183577,0.0002417269,0.0001051789,0.00006381827,0.0002284528,0.002283433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005995443,"about_ca_system_score_gemma":0.00006339163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003174752,"about_ca_topic_score_gemma":0.0001945728,"domain_scores_codex":[0.9982847,0.0004593833,0.0002808673,0.0003804486,0.00008891756,0.0005056639],"domain_scores_gemma":[0.9991306,0.000107927,0.0001296026,0.000407096,0.0001564232,0.0000683742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005769602,0.0002881634,0.004558799,0.000004534121,0.0004686561,0.00001604304,0.001405844,0.000002312555,0.9814207,0.000004075456,0.004680937,0.006572982],"study_design_scores_gemma":[0.002807718,0.0009373319,0.01156168,0.00004058249,0.0001101506,0.000006040638,0.001174545,0.00002457464,0.9730477,0.00003619136,0.01004573,0.000207761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909273,0.0009231386,0.0001127164,0.0004224303,0.0002545264,0.0005285133,0.006421536,0.00005369989,0.0003561233],"genre_scores_gemma":[0.9964594,0.00006861104,0.0001120987,0.00011791,0.00009883571,0.00005387274,0.001164407,0.00002358673,0.001901273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008372993,"threshold_uncertainty_score":0.9984934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758332784544402,"score_gpt":0.2480992418893185,"score_spread":0.2305159140438745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}