{"id":"W2900596044","doi":"10.1007/s00726-018-2674-8","title":"Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases","year":2018,"lang":"en","type":"article","venue":"Amino Acids","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Apelin; Kexin; Proprotein convertase; Furin; Proprotein Convertases; Gene isoform; Chemistry; Western blot; Cell culture; Extracellular; Receptor; Peptide; Cell biology; Biochemistry; Biology; Enzyme; LDL receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004226,0.0002547294,0.0003297397,0.0002109211,0.00007292225,0.00004937121,0.0001959487,0.0003267199,0.001023901],"category_scores_gemma":[0.0001661061,0.0001805172,0.00004187406,0.0006058569,0.0003840911,0.0002181866,0.0000677519,0.0005926102,0.0008524997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001297413,"about_ca_system_score_gemma":0.0003023516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002570593,"about_ca_topic_score_gemma":0.00003811162,"domain_scores_codex":[0.997222,0.00006709993,0.0004325087,0.0005972813,0.001120153,0.0005609423],"domain_scores_gemma":[0.9987458,0.00004309347,0.0001087449,0.0004091724,0.0003940375,0.0002991818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005335537,0.002358902,0.01642691,0.001030938,0.0001219281,0.0005379472,0.002286586,0.000004464029,0.9361659,0.00002828119,0.005282003,0.03042061],"study_design_scores_gemma":[0.009439555,0.008021588,0.01510771,0.0004316299,0.0001690369,0.00006174818,0.0006842795,0.02786882,0.9296846,0.0001089475,0.00781913,0.0006029414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923214,0.0003015027,0.001719192,0.00243276,0.00003153944,0.001885962,0.00001379878,0.00009845052,0.001195414],"genre_scores_gemma":[0.9833255,0.00002819704,0.001059707,0.0005745326,0.0001611668,0.0001376943,0.00009581447,0.00006162201,0.01455577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02981767,"threshold_uncertainty_score":0.9999254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532609649608486,"score_gpt":0.2768182047688326,"score_spread":0.2614921082727477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}