{"id":"W2900596044","doi":"10.1007/s00726-018-2674-8","title":"Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases","year":2018,"lang":"en","type":"article","venue":"Amino Acids","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Apelin; Kexin; Proprotein convertase; Furin; Proprotein Convertases; Gene isoform; Chemistry; Western blot; Cell culture; Extracellular; Receptor; Peptide; Cell biology; Biochemistry; Biology; Enzyme; LDL receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767261,0.0004460529,0.0002798401,0.0003006178,0.0002007737,0.0006546295,0.0001683698,0.0002847385,0.002076277],"category_scores_gemma":[0.0002855999,0.0001323988,0.0003348974,0.000236723,0.0001956223,0.0004583334,0.0002595185,0.0008666249,0.0009195782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265825,"about_ca_system_score_gemma":0.0002100527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003502691,"about_ca_topic_score_gemma":0.000358464,"domain_scores_codex":[0.9997525,0.00004896738,0.00003418207,0.0000517778,0.00006038568,0.00005220087],"domain_scores_gemma":[0.9996971,0.00007861616,0.00005210343,0.00005622828,0.00005647485,0.00005953992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002506459,0.0000200217,0.00008734901,0.00001625806,0.000004032896,0.000110707,0.00001060359,0.000006366528,0.9988586,0.0000398727,0.00002515558,0.0005703761],"study_design_scores_gemma":[0.00001403503,0.0001498522,0.005002343,0.000003321312,0.00001313805,0.0004826935,0.00003730484,0.0001532147,0.9921857,0.00003993392,0.001914463,0.00000405096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859385,0.003015832,0.005446411,0.0002088062,0.0001444314,0.00004348693,0.001193405,0.00008432292,0.003924852],"genre_scores_gemma":[0.9796943,0.001799154,0.005625486,0.000147766,0.0000546,0.00007617869,0.003415575,0.00005122332,0.009135704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002076277,"threshold_uncertainty_score":0.006945789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532609649608486,"score_gpt":0.2768182047688326,"score_spread":0.2614921082727477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}