{"id":"W2900632426","doi":"10.1016/j.phrs.2018.11.026","title":"Understanding antidepressant tachyphylaxis","year":2018,"lang":"en","type":"letter","venue":"Pharmacological Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; St Joseph's Health Care; Parkwood Institute","funders":"","keywords":"Medicine; Internal medicine; Lung cancer; Hazard ratio; Statin; Confidence interval; Proportional hazards model; Subgroup analysis; Meta-analysis; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006850835,0.000262582,0.0004527383,0.0004023317,0.0004228871,0.00009214402,0.0002777993,0.0006224826,0.007058374],"category_scores_gemma":[0.0002876585,0.0001779789,0.0001906469,0.000531688,0.0006453522,0.00005874133,0.0002216944,0.003581816,0.0008987316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001472,"about_ca_system_score_gemma":0.000500555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005893786,"about_ca_topic_score_gemma":0.000001456632,"domain_scores_codex":[0.9962128,0.0003614946,0.0002744819,0.0006981846,0.001442912,0.00101006],"domain_scores_gemma":[0.9980819,0.0008842285,0.00006041936,0.0003169652,0.0004104483,0.0002459896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001186627,0.0001581927,0.0004721055,0.0001540938,0.0005553543,0.003873799,0.00004932239,1.929632e-7,0.0006377294,0.00007905779,0.9934269,0.0004745405],"study_design_scores_gemma":[0.001411954,0.00100863,0.0004466713,0.0001118811,0.0003813714,0.00005934,0.0000445158,0.00005815322,0.0007422329,0.002033599,0.9935104,0.0001912237],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002364264,0.0008856927,0.0002353327,0.8671212,0.0007036404,0.001838373,0.0001124715,0.0001773931,0.1265617],"genre_scores_gemma":[0.2292565,0.001543381,0.0005800524,0.7002782,0.01861928,0.000686595,0.000805961,0.0001428359,0.04808719],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2268922,"threshold_uncertainty_score":0.9998792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5150994968715334,"score_gpt":0.5427440215124751,"score_spread":0.02764452464094169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}