{"id":"W2900662379","doi":"10.1182/blood-2018-99-112572","title":"Checkpoint Inhibitors Augment CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy in Relapsed B-Cell Acute Lymphoblastic Leukemia","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Cytokine release syndrome; Medicine; Chimeric antigen receptor; CD19; T cell; Internal medicine; Immunology; B cell; Blinatumomab; Pembrolizumab; Oncology; Immunotherapy; Antigen; Immune system; Cancer; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005373072,0.0004459744,0.0006776451,0.0004537549,0.0001266244,0.00004791869,0.0003159557,0.0002902877,0.004308338],"category_scores_gemma":[0.00006238907,0.0003917497,0.0002554928,0.00117204,0.0002534586,0.00007037296,0.0001222558,0.0005019406,0.0008400789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000606096,"about_ca_system_score_gemma":0.0007670706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005358689,"about_ca_topic_score_gemma":0.00004637082,"domain_scores_codex":[0.9966068,0.0002074631,0.0006878069,0.0007814703,0.000801508,0.0009150128],"domain_scores_gemma":[0.9982536,0.000117376,0.0001833969,0.0008430209,0.0002217524,0.0003808749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001225561,0.001846648,0.007518595,0.00005435997,0.0002315433,0.0001114254,0.001077288,0.000001799317,0.9815207,0.000001178422,0.002745808,0.003665101],"study_design_scores_gemma":[0.02253923,0.002931827,0.010046,0.0001474096,0.0001023322,0.00004476732,0.0001204737,0.0001926603,0.9531388,0.00001552901,0.01031935,0.0004016116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983422,0.0009340824,0.000008052916,0.0001984199,0.0005128229,0.001343143,0.0000160415,0.0002897411,0.01327566],"genre_scores_gemma":[0.9824382,0.001666738,0.001130305,0.0003267381,0.0009934189,0.0001207287,0.00007389964,0.0001599076,0.01309007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02838188,"threshold_uncertainty_score":0.9999379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384044587968382,"score_gpt":0.262182242261462,"score_spread":0.2483417963817782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}