{"id":"W2900662379","doi":"10.1182/blood-2018-99-112572","title":"Checkpoint Inhibitors Augment CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy in Relapsed B-Cell Acute Lymphoblastic Leukemia","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Cytokine release syndrome; Medicine; Chimeric antigen receptor; CD19; T cell; Internal medicine; Immunology; B cell; Blinatumomab; Pembrolizumab; Oncology; Immunotherapy; Antigen; Immune system; Cancer; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257217,0.0002440584,0.0003979613,0.0002047522,0.0002156102,0.0002695801,0.000203457,0.0001713144,0.0008429347],"category_scores_gemma":[0.0003563996,0.0001057466,0.0001949746,0.000163351,0.000179704,0.000131389,0.0001613028,0.000465613,0.0002764909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003491426,"about_ca_system_score_gemma":0.0002185448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005471999,"about_ca_topic_score_gemma":0.001176455,"domain_scores_codex":[0.9998682,0.00004706235,0.00001215831,0.00002146363,0.00001685048,0.00003429889],"domain_scores_gemma":[0.9998565,0.00004372979,0.00002976677,0.00001165283,0.000008132398,0.00005021953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02288511,0.00850075,0.3138882,0.0006990083,0.0006654738,0.01518287,0.001227337,0.005588052,0.2270336,0.0004509237,0.004196965,0.3996817],"study_design_scores_gemma":[0.01139446,0.1259821,0.5362427,0.0001484613,0.001184884,0.05947674,0.0005230171,0.008783582,0.2250465,0.0003113279,0.0308536,0.00005268786],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986727,0.0005682412,0.0001918357,0.00003473512,0.000004933579,0.00002175288,0.0000377139,0.0000246997,0.000443417],"genre_scores_gemma":[0.9989228,0.0003172493,0.0002985077,0.00003579687,0.00001092653,0.00002157509,0.0001284606,0.000006895405,0.0002577033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008429347,"threshold_uncertainty_score":0.002819896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384044587968382,"score_gpt":0.262182242261462,"score_spread":0.2483417963817782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}