{"id":"W2900733038","doi":"10.1182/blood-2018-99-118344","title":"Mosunetuzumab, a Full-Length Bispecific CD20/CD3 Antibody, Displays Clinical Activity in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (NHL): Interim Safety and Efficacy Results from a Phase 1 Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Tolerability; Mantle cell lymphoma; Internal medicine; Follicular lymphoma; CD20; Lymphoma; Gastroenterology; Rituximab; Refractory (planetary science); Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002314826,0.000533737,0.001251403,0.0003839487,0.0001835453,0.00009246671,0.0004289988,0.0004075615,0.0006999882],"category_scores_gemma":[0.0007282702,0.00047419,0.0002488129,0.0006491899,0.0006309763,0.0001656305,0.0004561668,0.0009881973,0.0001750118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002142084,"about_ca_system_score_gemma":0.0004103051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166926,"about_ca_topic_score_gemma":0.000639182,"domain_scores_codex":[0.9946628,0.0008106283,0.001340037,0.001549579,0.0008143508,0.0008226656],"domain_scores_gemma":[0.9955834,0.001659728,0.0003386728,0.001658267,0.0001831219,0.0005768627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1382599,0.106252,0.04595418,0.00008220778,0.0008151402,0.001966712,0.006807724,6.647323e-7,0.5339423,0.000002671472,0.0007901817,0.1651263],"study_design_scores_gemma":[0.3506332,0.03810691,0.5725709,0.000490074,0.0005326699,0.0001112714,0.001249117,0.001433756,0.01880477,0.0000148769,0.01517338,0.0008790983],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922761,0.0002534038,0.00006508209,0.0001955468,0.0004472588,0.00215687,0.0002766436,0.0001124051,0.004216691],"genre_scores_gemma":[0.9962737,0.0006338431,0.0003036033,0.00007840587,0.00115188,0.00003274835,0.0001493735,0.0001130391,0.001263415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5266167,"threshold_uncertainty_score":0.999771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04516121939774342,"score_gpt":0.3896615740049443,"score_spread":0.3445003546072009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}