{"id":"W2900782570","doi":"10.1016/j.neuropharm.2018.11.029","title":"The high efficacy of muscarinic M4 receptor in D1 medium spiny neurons reverses striatal hyperdopaminergia","year":2018,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Servier; Vetenskapsrådet; Agence Nationale de la Recherche; Horizon 2020 Framework Programme; Swedish e-Science Research Centre; National Alliance for Research on Schizophrenia and Depression","keywords":"Medium spiny neuron; Muscarinic acetylcholine receptor; Acetylcholine; Dopamine; Striatum; Oxotremorine; Muscarinic acetylcholine receptor M4; Neuroscience; Muscarinic acetylcholine receptor M1; Agonist; Dopamine receptor; Chemistry; Dopamine receptor D1; Pharmacology; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004131587,0.0006770662,0.0008379651,0.000666982,0.0004429099,0.0006435635,0.0008825446,0.0008294995,0.003766122],"category_scores_gemma":[0.0004947817,0.0004297262,0.0005084433,0.0002783901,0.0009344163,0.000754392,0.0004371266,0.002388482,0.0007109037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008934669,"about_ca_system_score_gemma":0.0008605951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002598795,"about_ca_topic_score_gemma":0.005394015,"domain_scores_codex":[0.9996188,0.00005512085,0.0000443348,0.00004831424,0.00006713554,0.0001662959],"domain_scores_gemma":[0.9995124,0.00009049729,0.00007923482,0.00007522757,0.00005446223,0.0001881998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001065749,0.0001701138,0.000187813,0.00006754441,0.00003863178,0.0001034034,0.000042981,0.00006743184,0.9956796,0.0004013766,0.0001564927,0.002019003],"study_design_scores_gemma":[0.0001373105,0.001097066,0.001684697,0.000006695149,0.00005846408,0.0001564443,0.00004590295,0.0004642759,0.9952223,0.00008080942,0.001036258,0.000009834318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962397,0.0006723466,0.000926313,0.0003222399,0.00009494831,0.00003904196,0.0003111078,0.0001302473,0.001264259],"genre_scores_gemma":[0.9912095,0.0006856445,0.001660235,0.0001192376,0.00005384118,0.00007190085,0.0004585192,0.00005346306,0.005687628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003766122,"threshold_uncertainty_score":0.01259893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103945140620933,"score_gpt":0.2694742814453448,"score_spread":0.2584348300391355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}