{"id":"W2900804033","doi":"10.1002/anie.201810179","title":"Design, Synthesis and Characterization of Covalent KDM5 Inhibitors","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; H2020 Marie Skłodowska-Curie Actions; Engineering and Physical Sciences Research Council; Innovative Medicines Initiative; Arthritis Research UK; Rosetrees Trust; Versus Arthritis; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cancer Research UK; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institute for Health and Care Research; Pfizer","keywords":"Chemistry; H3K4me3; Covalent bond; Histone; Biochemistry; Cysteine; Gene expression; Lysine; Gene; Cell biology; Biology; Enzyme; Promoter; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003028622,0.0003977066,0.0002344939,0.0001991738,0.0001732028,0.0002310445,0.0004506686,0.0003094654,0.001085754],"category_scores_gemma":[0.0002739214,0.0001744104,0.0002538065,0.0001736604,0.0001358214,0.0001744966,0.0002175496,0.0004164236,0.0005629982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005107348,"about_ca_system_score_gemma":0.0002358582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004261284,"about_ca_topic_score_gemma":0.001012201,"domain_scores_codex":[0.9998364,0.00001739491,0.00001686014,0.0000322593,0.00006357546,0.00003353036],"domain_scores_gemma":[0.999908,0.000009533851,0.00002829864,0.00001096311,0.00002435615,0.00001893362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008212281,0.00006764303,0.0001569798,0.0002359742,0.00002450679,0.00006973136,0.00002692774,0.001318384,0.986864,0.0007349103,0.0002981003,0.01012086],"study_design_scores_gemma":[0.00001782612,0.0003097368,0.0003074442,0.000007308686,0.00001577547,0.00006755946,0.000007230808,0.0008367424,0.9882795,0.00004503788,0.01009993,0.000006025955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8431788,0.01338536,0.1210743,0.0004299095,0.0001658319,0.001651795,0.003221615,0.0005105996,0.01638188],"genre_scores_gemma":[0.9425491,0.005648348,0.04096127,0.0001876244,0.00002240685,0.0004548366,0.001917653,0.00005779208,0.008200997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085754,"threshold_uncertainty_score":0.00370568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502311540909584,"score_gpt":0.2531192903859939,"score_spread":0.2380961749768981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}