{"id":"W2900877048","doi":"10.1136/annrheumdis-2018-eular.5665","title":"SAT0560 From a 2-year multicentre clinical trial in knee osteoarthritis, a metabolomic analysis reveals that over activation of the conversion pathway of phosphatidylcholine to lysophosphatidylcholine is associated with knee cartilage volume loss over time","year":2018,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Hematological disorders and diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Osteoarthritis; Metabolite; Internal medicine; Metabolomics; Cartilage; Rheumatology; Magnetic resonance imaging; Lysophosphatidylcholine; Metabolome; Pathology; Phosphatidylcholine; Bioinformatics; Radiology; Phospholipid; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001357471,0.0006039497,0.00131479,0.0002623679,0.0002965695,0.000912802,0.0002856108,0.0007876299,0.00345174],"category_scores_gemma":[0.001223242,0.0002016741,0.001300393,0.000416535,0.0003199848,0.0003613416,0.0003463259,0.00111287,0.0005058031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230664,"about_ca_system_score_gemma":0.0004632664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004303736,"about_ca_topic_score_gemma":0.001073648,"domain_scores_codex":[0.9995741,0.000143581,0.00005589376,0.00009104575,0.0000671399,0.00006833098],"domain_scores_gemma":[0.9994602,0.0001409874,0.0001243545,0.0000583348,0.00006827422,0.0001478806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.5693758,0.006501899,0.1033022,0.001720601,0.01161171,0.0009021264,0.0001825322,0.001639069,0.1569566,0.0004285233,0.008185889,0.139193],"study_design_scores_gemma":[0.1101301,0.2061661,0.6327854,0.0001445698,0.01194612,0.001806953,0.0002549981,0.002543462,0.02072241,0.0007273246,0.01262389,0.0001486834],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916764,0.004337071,0.0003104,0.0005642542,0.0001558653,0.0001027399,0.001849,0.00004793878,0.0009563557],"genre_scores_gemma":[0.9931509,0.001062101,0.0004527718,0.0006606284,0.000124171,0.00007865202,0.00363649,0.00001027657,0.0008239149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00345174,"threshold_uncertainty_score":0.01154721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03314796820682456,"score_gpt":0.3123808831993665,"score_spread":0.279232914992542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}