{"id":"W2900894091","doi":"10.1124/jpet.118.251157","title":"Convulsant Effects of Abused Synthetic Cannabinoids JWH-018 and 5F-AB-PINACA Are Mediated by Agonist Actions at CB1 Receptors in Mice","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Drug Abuse; United States Drug Enforcement Administration; National Center for Research Resources; National Institute of General Medical Sciences; University of Kentucky; Translational Research Institute, University of Arkansas for Medical Sciences; Hamilton Health Sciences Foundation; National Institutes of Health","keywords":"Convulsant; Pentylenetetrazol; Pharmacology; Agonist; Chemistry; Cannabinoid; Cannabinoid receptor; Seizure threshold; Anticonvulsant; Convulsion; Diazepam; Receptor; Medicine; Epilepsy; Biochemistry; Neuroscience; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004683743,0.001359717,0.0007610937,0.002591901,0.0006683558,0.0007566033,0.001063843,0.001324855,0.004386056],"category_scores_gemma":[0.0003116112,0.0008541128,0.001198244,0.0006124297,0.001634569,0.00128841,0.0004654499,0.004313746,0.00105936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0012729,"about_ca_system_score_gemma":0.001109829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003913595,"about_ca_topic_score_gemma":0.006977441,"domain_scores_codex":[0.999225,0.00009087552,0.00009308285,0.0001511811,0.0001869527,0.0002530411],"domain_scores_gemma":[0.9993364,0.00006487127,0.0002081191,0.00007494482,0.00005450288,0.0002610904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002733171,0.0006813415,0.0003840293,0.00007663472,0.00003733489,0.0003012875,0.0001240309,0.0001381993,0.9925457,0.0006274199,0.0002529784,0.002097807],"study_design_scores_gemma":[0.0003686667,0.002469311,0.004780595,0.00003829759,0.0001194937,0.0006149283,0.0001817244,0.001152541,0.9877246,0.0002695671,0.002232276,0.00004797222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934505,0.000852944,0.001358178,0.0004286094,0.00009083062,0.00006895612,0.001733402,0.0002223381,0.001794197],"genre_scores_gemma":[0.9761086,0.001990939,0.002715782,0.0004061586,0.00004959468,0.0003178632,0.001911998,0.0001634607,0.01633565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004386056,"threshold_uncertainty_score":0.01467288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873135195818722,"score_gpt":0.3501283085154936,"score_spread":0.3313969565573064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}