{"id":"W2900900488","doi":"10.1101/474163","title":"Elevation of intracellular levels of nitric oxide in SHR attenuates hyperproliferation of vascular smooth muscle cells through the inhibition of AT1 receptor expression and c-Src/growth factor receptor signaling pathways","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies","keywords":"Internal medicine; Endocrinology; Vascular smooth muscle; Angiotensin II; Angiotensin II receptor type 1; Intracellular; Receptor; Signal transduction; Chemistry; Nitric oxide; Sodium nitroprusside; Biology; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333245,0.0003226155,0.0003698522,0.0001563716,0.0001297847,0.0001147284,0.0001160201,0.0001673558,0.001004324],"category_scores_gemma":[0.00008029157,0.0001298712,0.0001783249,0.00006407197,0.0001711882,0.0001326342,0.000133303,0.0006471182,0.0001494554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008676334,"about_ca_system_score_gemma":0.0001287875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003485214,"about_ca_topic_score_gemma":0.0007341109,"domain_scores_codex":[0.9999192,0.00001766272,0.000007347905,0.00001209082,0.00001832367,0.00002535633],"domain_scores_gemma":[0.999908,0.000008971029,0.00002899637,0.000008622698,0.00001263196,0.00003278482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003024732,0.0000798878,0.0001696962,0.00004989649,0.000006358277,0.00003546366,0.0000148822,0.00002338619,0.9979104,0.0000254087,0.00002759288,0.001354439],"study_design_scores_gemma":[0.0001146288,0.004217338,0.01987453,0.00001907053,0.0000636935,0.0002753787,0.00007479228,0.001272173,0.9720432,0.00007180421,0.00196532,0.000008031784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969376,0.001437884,0.0009079587,0.00008426249,0.00002860646,0.00001627552,0.0000801563,0.00004213809,0.0004651673],"genre_scores_gemma":[0.9952238,0.001435363,0.001429289,0.00006576459,0.00003833147,0.000042074,0.0001674397,0.000008826542,0.001589099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004324,"threshold_uncertainty_score":0.003359854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0197163210308646,"score_gpt":0.2190227293153363,"score_spread":0.1993064082844717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}