{"id":"W2900903500","doi":"10.1016/j.ijantimicag.2018.11.017","title":"Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants","year":2018,"lang":"en","type":"article","venue":"International Journal of Antimicrobial Agents","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Capital Health","keywords":"Latamoxef; Dosing; Medicine; Pharmacokinetics; Regimen; Population; NONMEM; Pharmacodynamics; Pharmacology; Antibiotics; Internal medicine; Cephalosporin; Microbiology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825616,0.0000612617,0.0001505082,0.0001372861,0.00002457369,0.00002334552,0.00005301735,0.00002974055,0.00005543381],"category_scores_gemma":[0.0001138576,0.00005193774,0.00002368323,0.00006677858,0.00006818089,0.000227975,0.00005590211,0.00009979422,4.664128e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002529202,"about_ca_system_score_gemma":0.00001256437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000828518,"about_ca_topic_score_gemma":0.000008622662,"domain_scores_codex":[0.9993213,0.00002480667,0.0003309782,0.00006932233,0.0001824721,0.00007111341],"domain_scores_gemma":[0.9993454,0.00003926326,0.0002602671,0.00002267416,0.0002872535,0.00004520405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00220987,0.000252982,0.9302405,0.00007305495,0.000369249,0.00009348879,0.0008258783,0.0006571208,0.03939753,0.00003495315,0.0006274135,0.025218],"study_design_scores_gemma":[0.006713218,0.0003156764,0.9431628,0.0008942532,0.0002271675,0.0008986278,0.00008030149,0.01971849,0.02485048,0.00007950698,0.002906156,0.0001533389],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972329,0.0001830338,0.0003708029,0.001373577,0.0005442085,0.00005958596,0.000006976953,0.000002087555,0.0002268222],"genre_scores_gemma":[0.9944602,0.002133953,0.002737983,0.0004142851,0.0002307292,1.164877e-7,0.000005507875,0.000005283117,0.0000119557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02506466,"threshold_uncertainty_score":0.211796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03232171991516825,"score_gpt":0.3700230219480409,"score_spread":0.3377013020328727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}