{"id":"W2900925300","doi":"10.1002/hep4.1279","title":"Inhibition of Adenosine Monophosphate–Activated Protein Kinase–3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance","year":2018,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Ottawa","funders":"Canadian Institutes of Health Research; State Government of Victoria; Canadian Liver Foundation; Health Research","keywords":"AMPK; Internal medicine; Endocrinology; Insulin resistance; Protein kinase A; Biology; Sterol regulatory element-binding protein; AMP-activated protein kinase; Steatosis; Cholesterol; HMG-CoA reductase; Chemistry; Biochemistry; Reductase; Phosphorylation; Insulin; Enzyme; Sterol; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542099,0.000493569,0.0004117015,0.000317871,0.0001873264,0.0003582686,0.0002098995,0.0002794802,0.001608256],"category_scores_gemma":[0.00008321505,0.0002644982,0.0003908642,0.0002575598,0.0003359311,0.0001732867,0.0002031376,0.0009002472,0.0005179936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003272238,"about_ca_system_score_gemma":0.0002517541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007060351,"about_ca_topic_score_gemma":0.0009752468,"domain_scores_codex":[0.9997949,0.00003434036,0.00002523233,0.00003211116,0.00005366598,0.00005978798],"domain_scores_gemma":[0.9998653,0.00001954976,0.00004777799,0.00001497991,0.00000726795,0.00004513847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004181622,0.00009728175,0.0002285013,0.0000380773,0.00001338536,0.00006170649,0.00001000925,0.00005263394,0.9978258,0.00009762944,0.00008987425,0.001066926],"study_design_scores_gemma":[0.0001102564,0.0007842419,0.006089466,0.000007405432,0.0000398055,0.0002704746,0.0000336942,0.0009758638,0.9900304,0.00007728708,0.001575152,0.000006047776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994817,0.001456183,0.001613381,0.0002793587,0.00007273842,0.00002727584,0.0003320562,0.0002061768,0.001195829],"genre_scores_gemma":[0.9940403,0.001482102,0.001363581,0.00009536744,0.00002116579,0.00005439405,0.0004082761,0.00003016573,0.00250449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608256,"threshold_uncertainty_score":0.005380154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691407590434216,"score_gpt":0.265937286549668,"score_spread":0.2490232106453259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}