{"id":"W2900925300","doi":"10.1002/hep4.1279","title":"Inhibition of Adenosine Monophosphate–Activated Protein Kinase–3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance","year":2018,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Ottawa","funders":"Canadian Institutes of Health Research; State Government of Victoria; Canadian Liver Foundation; Health Research","keywords":"AMPK; Internal medicine; Endocrinology; Insulin resistance; Protein kinase A; Biology; Sterol regulatory element-binding protein; AMP-activated protein kinase; Steatosis; Cholesterol; HMG-CoA reductase; Chemistry; Biochemistry; Reductase; Phosphorylation; Insulin; Enzyme; Sterol; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002706457,0.0001890448,0.0003105308,0.0001003921,0.0002198237,0.00001983026,0.0002618023,0.0001853758,0.00001070225],"category_scores_gemma":[0.0002016185,0.0001972064,0.00003484758,0.0002364378,0.0006209931,0.00001571536,0.0003110023,0.0001557554,0.000003434155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001969317,"about_ca_system_score_gemma":0.00008511574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000121139,"about_ca_topic_score_gemma":0.0003849649,"domain_scores_codex":[0.9986367,0.0002765352,0.0003834307,0.0003755931,0.00008988743,0.0002379091],"domain_scores_gemma":[0.9984356,0.00004527966,0.0001729374,0.0009869899,0.0002368134,0.0001224438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001640105,0.0001200568,0.003189008,0.00006922331,0.0000483878,7.477142e-7,0.0005489785,5.747711e-7,0.9861122,0.0002327779,0.0002479962,0.009266039],"study_design_scores_gemma":[0.0006742488,0.0003162975,0.0008415814,0.0001532402,0.00006111507,0.000006338619,0.00008056773,0.0001050855,0.9833342,0.0003466983,0.01386329,0.0002173351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8910047,0.1075725,0.0001223987,0.000627045,0.00002659719,0.0005119872,0.00006952162,0.00001784706,0.00004737818],"genre_scores_gemma":[0.9827794,0.009793876,0.006614906,0.0003620288,0.00004421272,0.0002186956,0.0001400693,0.0000235074,0.00002329699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09777864,"threshold_uncertainty_score":0.8041846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691407590434216,"score_gpt":0.265937286549668,"score_spread":0.2490232106453259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}