{"id":"W2900927973","doi":"10.1038/s41541-018-0091-3","title":"Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate","year":2018,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Malaria Research and Control","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust; Fundação para a Ciência e a Tecnologia; Bill and Melinda Gates Foundation","keywords":"Plasmodium berghei; Parasite hosting; Malaria; Circumsporozoite protein; Plasmodium falciparum; Biology; Virology; In vivo; Rodent; Malaria vaccine; Anopheles stephensi; Antibody; Immunization; Immunology; Biotechnology; Aedes aegypti","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002758859,0.0002014815,0.0005639939,0.0001995793,0.00007456113,0.0000211114,0.0001948353,0.0001774267,0.004458961],"category_scores_gemma":[0.001509249,0.0001547414,0.000185814,0.0003533786,0.00004778847,0.0001016241,0.00005490134,0.0002547945,0.0001539152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005458003,"about_ca_system_score_gemma":0.0006902844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002624256,"about_ca_topic_score_gemma":0.0004043926,"domain_scores_codex":[0.997262,0.000306211,0.000714672,0.0004108653,0.0009068957,0.0003993727],"domain_scores_gemma":[0.996815,0.0002016552,0.0002244286,0.0007369476,0.001726624,0.0002953381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01859308,0.001620786,0.7549483,0.0003799748,0.0008645706,0.00004524229,0.0002065858,0.00004608731,0.03104243,0.0006169254,0.07352593,0.1181101],"study_design_scores_gemma":[0.01792609,0.002524858,0.9235623,0.0001559962,0.0006368732,0.00001442085,0.00001894276,0.04414568,0.004725239,0.00042178,0.005696452,0.0001713633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826429,0.0005963598,0.0006268297,0.01126963,0.0003980751,0.001428875,0.0000324729,0.00007526695,0.002929529],"genre_scores_gemma":[0.9954869,0.0000222965,0.0005763608,0.0005778755,0.001248739,0.00008670883,0.0001036212,0.00003050091,0.001867058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.168614,"threshold_uncertainty_score":0.9964511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03960282163426891,"score_gpt":0.3834959492660039,"score_spread":0.343893127631735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}