{"id":"W2900927973","doi":"10.1038/s41541-018-0091-3","title":"Pre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate","year":2018,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Malaria Research and Control","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust; Fundação para a Ciência e a Tecnologia; Bill and Melinda Gates Foundation","keywords":"Plasmodium berghei; Parasite hosting; Malaria; Circumsporozoite protein; Plasmodium falciparum; Biology; Virology; In vivo; Rodent; Malaria vaccine; Anopheles stephensi; Antibody; Immunization; Immunology; Biotechnology; Aedes aegypti","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005140704,0.0004394603,0.000316351,0.0001204875,0.00008664239,0.0002577768,0.0002173978,0.0002893123,0.001384799],"category_scores_gemma":[0.0003344934,0.0000950601,0.0001456006,0.00007187528,0.0002081209,0.0001633566,0.0001199278,0.0004582434,0.0003843565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518208,"about_ca_system_score_gemma":0.0002684813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000227516,"about_ca_topic_score_gemma":0.0004026038,"domain_scores_codex":[0.9998255,0.00005466582,0.00001086499,0.00002325159,0.00005491097,0.0000308134],"domain_scores_gemma":[0.9998533,0.00002015866,0.00003801929,0.000008886123,0.00004546926,0.00003420616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001839897,0.001261834,0.002197993,0.0004311445,0.00002710376,0.0001997781,0.00005353658,0.0005509725,0.9547098,0.0001437347,0.0006637485,0.03792062],"study_design_scores_gemma":[0.0006055071,0.1517905,0.023716,0.00009004411,0.0001980864,0.001738391,0.0001142899,0.002555328,0.797813,0.0001852746,0.02117586,0.00001774955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855059,0.004182151,0.006655791,0.0002901298,0.00007513795,0.0005870512,0.0005178683,0.0001289868,0.002056906],"genre_scores_gemma":[0.9935073,0.001434208,0.002346823,0.0001420443,0.00002736669,0.0001922853,0.0007723662,0.00001404636,0.001563617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384799,"threshold_uncertainty_score":0.004632592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03960282163426891,"score_gpt":0.3834959492660039,"score_spread":0.343893127631735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}