{"id":"W2900987965","doi":"10.1053/j.gastro.2018.11.024","title":"BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice","year":2018,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Princess Takamatsu Cancer Research Fund; Japan Agency for Medical Research and Development; Yasuda Memorial Medical Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Mitsubishi Foundation; National Cancer Institute; National Institutes of Health; Astellas Foundation for Research on Metabolic Disorders; Takeda Science Foundation","keywords":"LGR5; Biology; Enterocyte; Paneth cell; Stem cell; Intestinal epithelium; Progenitor cell; Cell biology; Cancer research; Small intestine; Epithelium; Molecular biology; Cancer stem cell; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120205,0.0001651946,0.000211934,0.0001279756,0.00002985891,0.000008404772,0.0001407673,0.0001156937,0.00001213981],"category_scores_gemma":[0.00007297293,0.0001748357,0.00002842098,0.00008290975,0.0001832247,0.000002527845,0.0001323198,0.0001465314,0.00001503718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003239331,"about_ca_system_score_gemma":0.00003982542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002391361,"about_ca_topic_score_gemma":0.005471316,"domain_scores_codex":[0.9986687,0.0001902024,0.0002278387,0.0004425184,0.0000536109,0.0004171467],"domain_scores_gemma":[0.9995753,0.00001804841,0.00006158175,0.0001546556,0.00006256081,0.0001278972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009063969,0.00007125625,0.06417632,0.000008552765,0.00001323864,0.0000352923,0.0008049051,0.00004081619,0.9334748,0.000002860086,0.0002348687,0.0002306874],"study_design_scores_gemma":[0.003087801,0.01105039,0.1077201,0.0001545605,0.00002242537,0.0001518762,0.0004317411,0.0003329343,0.8746592,0.00006276699,0.001983,0.0003432028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998738,0.00006471357,0.0002474848,0.0003658337,0.0001297392,0.000242811,0.0000617336,0.000008382403,0.0001412976],"genre_scores_gemma":[0.9978155,0.00001098768,0.0006913122,0.001112674,0.0001411196,0.00003757847,0.0000402665,0.00001788823,0.0001327102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05881561,"threshold_uncertainty_score":0.7129594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005211489241870178,"score_gpt":0.220810879136442,"score_spread":0.2155993898945718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}