{"id":"W2900988531","doi":"10.2147/ndt.s175203","title":"Optimized regimens of combined medications for the treatment of major depressive disorder: a double-blind, randomized-controlled trial","year":2018,"lang":"en","type":"article","venue":"Neuropsychiatric Disease and Treatment","topic":"Treatment of Major Depression","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"H. Lundbeck A/S; Sunovion; Australian Government; Les Laboratories Pierre Fabre; Pfizer; Allergan; Bristol-Myers Squibb","keywords":"Escitalopram; Bupropion; Medicine; Major depressive disorder; Internal medicine; Duloxetine; Combination therapy; Hamilton Rating Scale for Depression; Retention rate; Randomization; Clinical trial; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002749877,0.001428876,0.005567485,0.0009720493,0.0004742262,0.00124025,0.001206513,0.002120529,0.005813852],"category_scores_gemma":[0.003092759,0.001000258,0.00201726,0.0009049774,0.001245989,0.001220112,0.0006229895,0.002230195,0.000770541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000741691,"about_ca_system_score_gemma":0.001015719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006495905,"about_ca_topic_score_gemma":0.001210917,"domain_scores_codex":[0.9976363,0.001147471,0.0003258028,0.0004480492,0.0002530504,0.000189235],"domain_scores_gemma":[0.9981444,0.0006248986,0.0005932758,0.0001774792,0.0001234088,0.0003365312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9790015,0.005987321,0.0002241157,0.0009662244,0.001194948,0.00001594333,0.00001866352,0.0001873286,0.0008827219,0.00004755154,0.0001846378,0.01128903],"study_design_scores_gemma":[0.9645633,0.03409898,0.0004986215,0.00003214099,0.0003508944,0.000008721512,0.000004103032,0.0001619555,0.0001139997,0.00002729527,0.0001325701,0.000007451359],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714814,0.01369971,0.001449555,0.0004268637,0.0009604228,0.009092663,0.0009760953,0.0001906979,0.001722606],"genre_scores_gemma":[0.9717273,0.006553131,0.004957858,0.0008594501,0.001270458,0.01208985,0.0008214652,0.00003113546,0.001689382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005813852,"threshold_uncertainty_score":0.01944929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819243741665734,"score_gpt":0.3001341824840717,"score_spread":0.2819417450674144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}