{"id":"W2900996428","doi":"10.1038/s41386-018-0273-8","title":"Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder","year":2018,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Dalhousie University","funders":"U.S. Department of Veterans Affairs; National Institute of Mental Health; U.S. Department of Health and Human Services","keywords":"Circadian rhythm; Chronotype; Lithium (medication); Bipolar disorder; Internal medicine; Evening; Psychology; Endocrinology; Mood stabilizer; Mood; Mania; PER2; Medicine; Circadian clock; Psychiatry; CLOCK","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003704802,0.0002588156,0.000280088,0.0001647158,0.0002071944,0.00003374397,0.0002518486,0.00011128,0.0001254034],"category_scores_gemma":[0.0002799798,0.0001714033,0.00005139951,0.0005253804,0.0006833766,0.00009418917,0.00007759503,0.0003428794,0.0002624521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007225636,"about_ca_system_score_gemma":0.0001239987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002497614,"about_ca_topic_score_gemma":0.00003923792,"domain_scores_codex":[0.9969665,0.001022372,0.0003758993,0.0008513523,0.0001834977,0.0006003969],"domain_scores_gemma":[0.9984754,0.0005963366,0.0001034619,0.0004511075,0.00005371726,0.0003200062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02538554,0.001536541,0.8380548,0.00001450115,0.00003914012,0.0005533663,0.002377524,0.00003981656,0.09354337,0.0004137662,0.003820392,0.03422129],"study_design_scores_gemma":[0.004915637,0.003695426,0.6732352,0.000009875353,0.00002002045,0.00002199862,0.000008619402,0.0001211811,0.004273598,0.000008074868,0.3135205,0.0001698286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930902,0.0001773491,0.00004493662,0.003461221,0.001648648,0.001205017,0.00003175579,0.0000538064,0.0002870966],"genre_scores_gemma":[0.9917777,0.0001221005,0.00003032252,0.006779914,0.0003582955,0.00009744632,0.000001278642,0.00004632563,0.0007866236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3097001,"threshold_uncertainty_score":0.6989625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728622588852644,"score_gpt":0.2961281615687036,"score_spread":0.2788419356801771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}