{"id":"W2900996428","doi":"10.1038/s41386-018-0273-8","title":"Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder","year":2018,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Dalhousie University","funders":"U.S. Department of Veterans Affairs; National Institute of Mental Health; U.S. Department of Health and Human Services","keywords":"Circadian rhythm; Chronotype; Lithium (medication); Bipolar disorder; Internal medicine; Evening; Psychology; Endocrinology; Mood stabilizer; Mood; Mania; PER2; Medicine; Circadian clock; Psychiatry; CLOCK","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916921,0.0002894411,0.0004821557,0.0003382248,0.0002953772,0.0004307018,0.0001348843,0.0003595455,0.0008576305],"category_scores_gemma":[0.001215933,0.0001364523,0.0002686024,0.000409215,0.0001523815,0.0002390228,0.0001639361,0.0004072434,0.0001094871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003619908,"about_ca_system_score_gemma":0.0002495859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003718734,"about_ca_topic_score_gemma":0.009794104,"domain_scores_codex":[0.9999038,0.00002835095,0.00001868183,0.00001509994,0.00001669668,0.00001737975],"domain_scores_gemma":[0.9994962,0.0001010339,0.000263783,0.00002181367,0.00004916706,0.00006792545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00175565,0.00009253706,0.9875485,0.00003310567,0.00014356,0.0001151768,0.00007968692,0.000103605,0.001740242,0.00002270215,0.0001878571,0.008177336],"study_design_scores_gemma":[0.00002086169,0.000140058,0.9992825,0.000005443394,0.0000319441,0.0001099381,0.00005659622,0.0001689812,0.00007327952,0.00002247775,0.00008484577,0.000003184438],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981698,0.001027296,0.00006065283,0.00008864841,0.00002472991,0.00000786623,0.0001007315,0.000005302804,0.0005149768],"genre_scores_gemma":[0.9993199,0.0002545766,0.0000845787,0.00005613133,0.00001588529,0.000005808723,0.0001294097,0.000001791954,0.0001319495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003718734,"threshold_uncertainty_score":0.007394195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01728622588852644,"score_gpt":0.2961281615687036,"score_spread":0.2788419356801771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}