{"id":"W2901006613","doi":"10.1038/s41386-018-0278-3","title":"Does relapse contribute to treatment resistance? Antipsychotic response in first- vs. second-episode schizophrenia","year":2018,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; University of Toronto; Centre for Addiction and Mental Health","funders":"H. Lundbeck A/S; Astellas Foundation for Research on Metabolic Disorders; Chinese University of Hong Kong; Astellas Pharma; Mylan; Pfizer; Dainippon Sumitomo Pharma; Neurocrine Biosciences; Canadian Institutes of Health Research; Sunovion; Japanese Society of Clinical Neuropsychopharmacology; F. Hoffmann-La Roche","keywords":"Schizoaffective disorder; Antipsychotic; Brief Psychiatric Rating Scale; Schizophrenia (object-oriented programming); Psychiatry; Psychosis; Psychology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000461453,0.0004701824,0.0007517823,0.0007191451,0.0002250651,0.00004080261,0.0002790283,0.0001838644,0.002272914],"category_scores_gemma":[0.0003322948,0.0003082318,0.0001875801,0.0009229723,0.000278042,0.00009658418,0.00007364965,0.0004268396,0.002048618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005323974,"about_ca_system_score_gemma":0.0003064516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004531503,"about_ca_topic_score_gemma":0.005261002,"domain_scores_codex":[0.9962138,0.0006141486,0.0006233848,0.001091981,0.000376428,0.001080273],"domain_scores_gemma":[0.9973723,0.0006415481,0.000109807,0.000808472,0.0002143167,0.0008535811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8986101,0.00196537,0.01638857,0.00005560361,0.0003149079,0.005244407,0.0004164752,0.000003733456,0.05282639,0.0001723457,0.02062651,0.003375639],"study_design_scores_gemma":[0.06314404,0.01404597,0.7246429,0.0001368025,0.0001769859,0.0001902457,0.00002141555,0.00004425112,0.01447926,0.0006345263,0.1820322,0.0004514352],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622569,0.0002727786,0.000009476865,0.03253117,0.001997435,0.001962969,0.00007326501,0.0002241932,0.0006717978],"genre_scores_gemma":[0.9861811,0.0003177134,0.001201182,0.004235459,0.0006972913,0.0004824883,0.00001203104,0.0001020423,0.006770638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.835466,"threshold_uncertainty_score":0.999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598518669122424,"score_gpt":0.3236541421375455,"score_spread":0.3076689554463213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}