{"id":"W2901006613","doi":"10.1038/s41386-018-0278-3","title":"Does relapse contribute to treatment resistance? Antipsychotic response in first- vs. second-episode schizophrenia","year":2018,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":201,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; University of Toronto; Centre for Addiction and Mental Health","funders":"H. Lundbeck A/S; Astellas Foundation for Research on Metabolic Disorders; Chinese University of Hong Kong; Astellas Pharma; Mylan; Pfizer; Dainippon Sumitomo Pharma; Neurocrine Biosciences; Canadian Institutes of Health Research; Sunovion; Japanese Society of Clinical Neuropsychopharmacology; F. Hoffmann-La Roche","keywords":"Schizoaffective disorder; Antipsychotic; Brief Psychiatric Rating Scale; Schizophrenia (object-oriented programming); Psychiatry; Psychosis; Psychology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005251146,0.0002920979,0.001613729,0.0007448193,0.0005371458,0.001490241,0.0005774532,0.001507188,0.00300752],"category_scores_gemma":[0.0173555,0.0003030768,0.002069697,0.0006052061,0.0005776429,0.001305255,0.0007491009,0.002107458,0.0004637977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008969739,"about_ca_system_score_gemma":0.0007081156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002012683,"about_ca_topic_score_gemma":0.003816392,"domain_scores_codex":[0.9978216,0.001005102,0.0002842721,0.0002289951,0.0003251754,0.0003348212],"domain_scores_gemma":[0.9912062,0.003846354,0.002749639,0.0007659962,0.0004901043,0.0009416587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01731709,0.0006973369,0.9155423,0.0001757795,0.001546817,0.0006614794,0.0009173032,0.0004214145,0.003643764,0.0005401706,0.0008491799,0.0576873],"study_design_scores_gemma":[0.0002505427,0.001379667,0.9921967,0.00009983042,0.0004587083,0.00100512,0.0007709042,0.001621256,0.0003812695,0.001194497,0.0006064375,0.00003511942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995693,0.002104327,0.0001092897,0.0009707211,0.00004538019,0.00001402291,0.00009974244,0.00001153874,0.0009520895],"genre_scores_gemma":[0.9990795,0.0003362962,0.00004804307,0.0001875208,0.00005648051,0.000005370437,0.00008391095,0.000007291746,0.000195689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005251146,"threshold_uncertainty_score":0.027771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598518669122424,"score_gpt":0.3236541421375455,"score_spread":0.3076689554463213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}