{"id":"W2901026782","doi":"10.1182/blood-2018-99-111061","title":"Comparison of Efficacy and Toxicity of CD19-Specific Chimeric Antigen Receptor T-Cells Alone or in Combination with Ibrutinib for Relapsed and/or Refractory CLL","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ibrutinib; Medicine; Fludarabine; Internal medicine; Leukapheresis; Neutropenia; Chronic lymphocytic leukemia; Cyclophosphamide; Immunology; Leukemia; Gastroenterology; Toxicity; Chemotherapy; Stem cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001403631,0.0007109935,0.001909506,0.000564329,0.0002053618,0.0006649782,0.0006546083,0.0005150965,0.00120653],"category_scores_gemma":[0.0008473542,0.0003158443,0.000893607,0.0003762724,0.0005191457,0.0004258573,0.0002580596,0.001349266,0.0002370277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006631359,"about_ca_system_score_gemma":0.0007054321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008512712,"about_ca_topic_score_gemma":0.002193407,"domain_scores_codex":[0.999301,0.0003941781,0.00005416409,0.00008960767,0.00006857733,0.00009245106],"domain_scores_gemma":[0.999366,0.000204829,0.000126021,0.0000480972,0.00002950352,0.0002254899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6258879,0.03087512,0.0155239,0.001081291,0.002384641,0.0003832711,0.0003313025,0.007086529,0.1283373,0.0003419656,0.001299582,0.1864672],"study_design_scores_gemma":[0.09049971,0.8477609,0.02402339,0.00008577064,0.002254357,0.0003987039,0.00008857789,0.003169874,0.02921925,0.0001569967,0.002296639,0.00004588608],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957638,0.003023768,0.0001704201,0.00007111341,0.00004928315,0.0001643345,0.000148886,0.00002243494,0.0005859536],"genre_scores_gemma":[0.9980699,0.0008764393,0.000236727,0.00004816423,0.00008436141,0.0001344236,0.0002108819,0.000008045896,0.0003310397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001909506,"threshold_uncertainty_score":0.007423222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05115529306873292,"score_gpt":0.3441964048219737,"score_spread":0.2930411117532408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}