{"id":"W2901100357","doi":"10.1016/j.yjmcc.2018.07.064","title":"iPSC based multisystemic-disease models from patients of mitochondrial disorder display varied disease progression in different cell types","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Manitoba Health; University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Induced pluripotent stem cell; Disease; Phenotype; Genotype; Mitochondrial disease; Genotype-phenotype distinction; Clinical phenotype; Biology; Cell; Bioinformatics; Medicine; Genetics; Mitochondrial DNA; Pathology; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003372716,0.0003566284,0.0004194109,0.0006009904,0.0002645827,0.0006109789,0.0002717615,0.0005379161,0.003241582],"category_scores_gemma":[0.0002636254,0.0001507648,0.0005193235,0.000264801,0.0002567471,0.0003590548,0.0003768498,0.001423084,0.001307583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396105,"about_ca_system_score_gemma":0.0001156316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002012266,"about_ca_topic_score_gemma":0.0003242819,"domain_scores_codex":[0.9997076,0.00003247885,0.00006833385,0.00007139098,0.00008102736,0.00003911443],"domain_scores_gemma":[0.9996264,0.0001145787,0.0000690793,0.00008610679,0.0000420997,0.0000616957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005007641,0.0001375885,0.001733141,0.0001004165,0.00004814658,0.0008830208,0.0001333391,0.0002971606,0.9909034,0.0006697428,0.000354094,0.004239025],"study_design_scores_gemma":[0.00009383944,0.0009579696,0.02366104,0.00005630471,0.0002482078,0.007121368,0.0002469437,0.002709949,0.9510747,0.0006004885,0.01319686,0.00003232663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777603,0.001520169,0.01114705,0.0002228531,0.0001983535,0.0001124011,0.00392555,0.0003481501,0.004765272],"genre_scores_gemma":[0.9876335,0.0008611707,0.002968105,0.0001443555,0.00002668847,0.0001260781,0.004930092,0.00009071542,0.003219404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003241582,"threshold_uncertainty_score":0.01084411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006615855593170123,"score_gpt":0.2190029005279368,"score_spread":0.2123870449347667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}