{"id":"W2901108431","doi":"10.1016/j.immuni.2018.11.001","title":"Fc-Engineered Anti-4-1BB Antibodies Pack a One-Two Punch","year":2018,"lang":"en","type":"letter","venue":"Immunity","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Antibody; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005431444,0.0007236457,0.001382814,0.0004493712,0.0004137077,0.0001202189,0.0007366213,0.0009245111,0.002876107],"category_scores_gemma":[0.0003321768,0.0005930828,0.0005554231,0.0004121885,0.0007198378,0.0001240702,0.0005407396,0.005204862,0.003074011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001418042,"about_ca_system_score_gemma":0.0003768822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002220174,"about_ca_topic_score_gemma":0.00005358497,"domain_scores_codex":[0.995935,0.000338162,0.0006345604,0.0006145121,0.001270395,0.00120742],"domain_scores_gemma":[0.9969941,0.0004446639,0.0001865345,0.001501802,0.0006339113,0.0002390325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002353793,0.0002043409,0.002229947,0.001251544,0.0007769265,0.001015336,0.000201657,3.954869e-7,0.00346742,0.00002545545,0.9892412,0.001350353],"study_design_scores_gemma":[0.001188194,0.0006408101,0.02005809,0.0008163238,0.0002602711,0.0003215732,0.00003149486,0.00005890151,0.002410577,0.0002111871,0.9733379,0.0006646322],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3373696,0.003391066,0.00003455317,0.6062075,0.001370081,0.001264428,0.0009569133,0.0003819742,0.04902382],"genre_scores_gemma":[0.1094238,0.003966493,0.002697261,0.6251417,0.03240324,0.0001254907,0.01272378,0.0005097649,0.2130085],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2279458,"threshold_uncertainty_score":0.999652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06223765533400104,"score_gpt":0.3397744082525815,"score_spread":0.2775367529185805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}