{"id":"W2901108431","doi":"10.1016/j.immuni.2018.11.001","title":"Fc-Engineered Anti-4-1BB Antibodies Pack a One-Two Punch","year":2018,"lang":"en","type":"letter","venue":"Immunity","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Antibody; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000358959,0.0003645346,0.0003847191,0.0002364116,0.0006888933,0.0006053587,0.0006006915,0.005197481,0.01020824],"category_scores_gemma":[0.001140673,0.0002601472,0.0004447389,0.0001105947,0.000736631,0.0008860602,0.0003509031,0.005262989,0.005968972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006465316,"about_ca_system_score_gemma":0.0002905462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000452763,"about_ca_topic_score_gemma":0.0008546953,"domain_scores_codex":[0.9995891,0.0001085573,0.0000318157,0.00006024187,0.0001020171,0.0001082204],"domain_scores_gemma":[0.9995685,0.0002527356,0.00003356149,0.00005176077,0.00004270502,0.00005066648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002766937,0.001059307,0.003518245,0.000332904,0.000101407,0.05118383,0.0003794586,0.001026367,0.1412217,0.02674958,0.5426998,0.2289605],"study_design_scores_gemma":[0.0008174648,0.001482545,0.002753322,0.0001293624,0.0001228938,0.1037146,0.0003636321,0.006180979,0.104768,0.01600552,0.7635859,0.00007582079],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.183254,0.01392555,0.08292372,0.5389878,0.04981794,0.0005459535,0.0004665699,0.002844297,0.1272343],"genre_scores_gemma":[0.6177825,0.005394822,0.05531105,0.150167,0.00859355,0.0003190863,0.0003843674,0.0002208222,0.1618268],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01020824,"threshold_uncertainty_score":0.03415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06223765533400104,"score_gpt":0.3397744082525815,"score_spread":0.2775367529185805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}