{"id":"W2901111700","doi":"10.1016/j.yjmcc.2018.07.027","title":"Pathophysiology of R222Q mutant SCN5a channels","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; York University; University of Toronto","funders":"","keywords":"Flecainide; Mutant; Sodium channel; Induced pluripotent stem cell; Mutation; RNA splicing; Biology; Molecular biology; Internal medicine; Cell biology; Genetics; Chemistry; Medicine; Gene; Sodium; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002929759,0.0005307308,0.0003897719,0.000458355,0.0002445331,0.0005740561,0.0005964351,0.001505836,0.001168481],"category_scores_gemma":[0.0005498679,0.00016201,0.0002996635,0.0001386067,0.0009145418,0.0006888562,0.0003551832,0.0006824362,0.0002604115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005974555,"about_ca_system_score_gemma":0.0003507172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003531047,"about_ca_topic_score_gemma":0.0003087778,"domain_scores_codex":[0.9998447,0.0000421375,0.00002407264,0.00003399198,0.00002867333,0.00002636304],"domain_scores_gemma":[0.9998167,0.00004542911,0.00006798327,0.00001606482,0.00001912019,0.00003484108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003432987,0.0005553038,0.04116312,0.001003737,0.0002628122,0.2847206,0.001413924,0.003083113,0.5019239,0.07303259,0.006468654,0.08293934],"study_design_scores_gemma":[0.001190806,0.003461648,0.1411517,0.0006238036,0.00046343,0.6508185,0.001416297,0.01915584,0.061156,0.09043592,0.02999338,0.000132678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9140353,0.05299118,0.008616277,0.008247766,0.0006194835,0.0001077178,0.0001537738,0.0001551559,0.01507336],"genre_scores_gemma":[0.9914937,0.005350438,0.00111823,0.0005442932,0.0003539788,0.00002222828,0.00005432206,0.000008694098,0.001054142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001505836,"threshold_uncertainty_score":0.004334927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006239850006984773,"score_gpt":0.227696421646044,"score_spread":0.2214565716390593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}