{"id":"W2901112389","doi":"10.1038/s41467-018-07215-9","title":"Cellular metabolism constrains innate immune responses in early human ontogeny","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Michael Smith Health Research BC; BC Children's Hospital; Faculty of Medicine, University of British Columbia","keywords":"Biology; Immune system; Transcriptome; Innate immune system; Immunity; Cell biology; Immunology; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001232385,0.0001703959,0.0003448507,0.0005367818,0.0003796554,0.00003202957,0.001058411,0.0004185634,0.0001369036],"category_scores_gemma":[0.001222215,0.0001622682,0.00009096145,0.0008256354,0.0009174878,0.0001250651,0.0004704759,0.002520084,0.0002015529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001795462,"about_ca_system_score_gemma":0.0005399227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000390295,"about_ca_topic_score_gemma":0.001448849,"domain_scores_codex":[0.9977512,0.0005550895,0.0005056307,0.0002777068,0.000447811,0.0004625603],"domain_scores_gemma":[0.995774,0.0004305438,0.0001094138,0.00291916,0.0005165579,0.0002503206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001149143,0.001265419,0.03104668,0.000190006,0.0002259678,0.0001533969,0.00382705,1.340874e-7,0.8021885,0.1340867,0.00166853,0.02419855],"study_design_scores_gemma":[0.001769041,0.0002527913,0.3587525,0.0001175935,0.00003933129,0.00002126898,0.0001147825,0.00002989489,0.0233361,0.0004358982,0.6149439,0.0001869367],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9201646,0.05253124,0.00001136226,0.01073006,0.0001504216,0.0009729277,0.00005316105,0.0001175675,0.01526865],"genre_scores_gemma":[0.9940224,0.0006863226,0.002166207,0.001893167,0.0001271453,0.00008772578,0.00006989863,0.00003650646,0.0009106606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7788523,"threshold_uncertainty_score":0.9997811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07555276503299356,"score_gpt":0.425991841244008,"score_spread":0.3504390762110144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}