{"id":"W2901171758","doi":"10.1021/acs.jmedchem.8b01000","title":"Bisphosphonate Inhibitors of Mammalian Glycolytic Aldolase","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Agence Nationale de la Recherche; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Chemistry; Aldolase A; Glycolysis; Bisphosphonate; Biochemistry; Fructose-bisphosphate aldolase; Enzyme; Internal medicine; Osteoporosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032913,0.0004034169,0.0002390599,0.0001706339,0.00009859382,0.0002328102,0.0002821484,0.0001779099,0.0009286219],"category_scores_gemma":[0.0001011434,0.0001220434,0.0001613957,0.0001938825,0.0001252661,0.0001806648,0.0001769092,0.0004013287,0.0002571743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004275567,"about_ca_system_score_gemma":0.000283177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001561212,"about_ca_topic_score_gemma":0.003123993,"domain_scores_codex":[0.9999218,0.00001282028,0.000006346134,0.00001242198,0.00003058414,0.00001603007],"domain_scores_gemma":[0.9999737,0.000006190726,0.000006995117,0.000001948348,0.000005476997,0.000005642266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003545365,0.0002164958,0.0003895314,0.0002603299,0.00003799718,0.0001511903,0.00004067567,0.00558101,0.9750565,0.002395175,0.0005401486,0.01497644],"study_design_scores_gemma":[0.0001615462,0.0008235295,0.0009361557,0.00002118783,0.00003103356,0.000292732,0.00002486455,0.00544203,0.9764964,0.0003946444,0.01536071,0.00001513293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666708,0.01274083,0.008127001,0.0003247153,0.00008422081,0.0001349394,0.00101474,0.000199009,0.01070368],"genre_scores_gemma":[0.9785564,0.01070276,0.005158582,0.00008793766,0.00001281695,0.00007538684,0.001086211,0.0000171948,0.0043027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561212,"threshold_uncertainty_score":0.003106534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006437451189432012,"score_gpt":0.2464955455364367,"score_spread":0.2400580943470046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}