{"id":"W2901193757","doi":"10.1530/rep-18-0366","title":"Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos","year":2018,"lang":"en","type":"article","venue":"Reproduction","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Ste. Anne's Hospital","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Reprogramming; Somatic cell nuclear transfer; Embryo; Cell biology; RNA; Gene; Gene expression; Biology; Chemistry; Andrology; Genetics; Embryogenesis; Blastocyst; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006360412,0.0001025703,0.0001315718,0.0001233252,0.00007401784,0.00001405408,0.00008496077,0.0001041993,0.00001506801],"category_scores_gemma":[0.0004109474,0.0001059147,0.00005491965,0.00023032,0.0001233422,0.00001264151,0.00008519763,0.00007622413,0.00001152623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003543029,"about_ca_system_score_gemma":0.00003624162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006222239,"about_ca_topic_score_gemma":0.00003536513,"domain_scores_codex":[0.9985301,0.00009870807,0.0002849003,0.000655125,0.0002031006,0.0002280131],"domain_scores_gemma":[0.9990683,0.00000437017,0.0001176376,0.0005984533,0.0001750729,0.0000361953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001459843,0.00007700359,0.001768258,0.00007524993,0.00001668924,0.000003375462,0.0000742323,0.00002177493,0.9861333,0.000002216384,0.00005740752,0.01162454],"study_design_scores_gemma":[0.0001809882,0.000178924,0.005508663,0.00005977224,0.00000651338,0.00002610811,0.0001115864,0.00001218815,0.9930317,0.00001828242,0.0007607539,0.0001045223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979485,0.0008134019,0.0001795137,0.0001037269,0.0002235297,0.0002352158,0.000002378499,0.0000159835,0.0004777508],"genre_scores_gemma":[0.9974219,0.0003142707,0.0007640452,0.000004208433,0.0007508697,0.00004785202,0.0000172164,0.00001699463,0.0006626534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01152002,"threshold_uncertainty_score":0.4319077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407001368563287,"score_gpt":0.2587505053761661,"score_spread":0.2446804916905332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}