{"id":"W2901204777","doi":"10.1182/blood-2018-99-116868","title":"Single Agent Oral Selinexor Demonstrates Deep and Durable Responses in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) in Both GCB and Non-GCB Subtypes: The Phase 2b Sadal Study","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Diffuse large B-cell lymphoma; Medicine; Refractory (planetary science); Lymphoma; Ibrutinib; Internal medicine; Leukemia; Chronic lymphocytic leukemia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001172008,0.0008716463,0.00127838,0.0003484624,0.0002087961,0.0006645787,0.0005676534,0.0006180751,0.002652023],"category_scores_gemma":[0.0004195423,0.0003886738,0.0008902767,0.000202624,0.0005460497,0.000571769,0.000288998,0.001977945,0.0005676938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004877757,"about_ca_system_score_gemma":0.000707282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005571698,"about_ca_topic_score_gemma":0.002147194,"domain_scores_codex":[0.9997156,0.0001476637,0.00001804297,0.00003774007,0.00003475605,0.00004616419],"domain_scores_gemma":[0.9996388,0.00006250069,0.00006671456,0.00003259309,0.00003061791,0.0001686808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6095414,0.085932,0.01180612,0.001619826,0.002026895,0.0002596559,0.0003744895,0.002376927,0.1191689,0.0003258763,0.004262742,0.1623052],"study_design_scores_gemma":[0.4301363,0.5333961,0.02268114,0.00004578602,0.0005757503,0.0003967024,0.0001046955,0.001210037,0.007974765,0.0001552381,0.003289323,0.00003415493],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967758,0.001113867,0.000191387,0.0001798592,0.0000277445,0.0004780938,0.0004196254,0.00004764386,0.00076601],"genre_scores_gemma":[0.9948871,0.001024645,0.0007224646,0.0003242438,0.00005238317,0.0004955641,0.001078848,0.00001485731,0.001399921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002652023,"threshold_uncertainty_score":0.008871913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685860116098989,"score_gpt":0.2733160945926091,"score_spread":0.2564574934316192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}