{"id":"W2901208879","doi":"10.1172/jci121004","title":"Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; Ottawa Hospital; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Ontario Institute for Cancer Research","keywords":"Immunotherapy; Oncolytic virus; Immunology; Medicine; Melanoma; Cancer immunotherapy; Immunosuppression; Blockade; Tumor microenvironment; Antigen; Cancer research; Immune system; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636592,0.0003754581,0.0003774085,0.0002265054,0.0001070136,0.0002999445,0.000158655,0.0002119165,0.0008778957],"category_scores_gemma":[0.0001106054,0.00008900705,0.0001702455,0.0001111746,0.0002408786,0.0001934051,0.0001611664,0.0009711565,0.0001935069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632709,"about_ca_system_score_gemma":0.0002954435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001343335,"about_ca_topic_score_gemma":0.0003741391,"domain_scores_codex":[0.9998628,0.00002947498,0.0000153887,0.0000183014,0.00003373505,0.00004036467],"domain_scores_gemma":[0.9998982,0.00002308319,0.00002657498,0.00001829908,0.000008088216,0.00002577804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003530068,0.000159564,0.0002815807,0.0000465495,0.000007202179,0.00005698438,0.00001257553,0.0002392851,0.9918002,0.0003023315,0.00005712204,0.006683532],"study_design_scores_gemma":[0.00009758645,0.002110909,0.001837682,0.00001074746,0.00002162653,0.0003137004,0.00001486889,0.001274998,0.9919766,0.0001985657,0.002139475,0.000003394259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921112,0.001303275,0.003739991,0.0001114352,0.00006770554,0.00005268871,0.0001016157,0.0001312711,0.002380863],"genre_scores_gemma":[0.9964521,0.0005955016,0.001511757,0.00005673412,0.00002797713,0.0000439884,0.00008458068,0.000020696,0.001206666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008778957,"threshold_uncertainty_score":0.00293684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08244466000754858,"score_gpt":0.4013946222974213,"score_spread":0.3189499622898728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}