{"id":"W2901215603","doi":"10.1007/s10295-018-2097-2","title":"Heterologous expression-facilitated natural products’ discovery in actinomycetes","year":2018,"lang":"en","type":"review","venue":"Journal of Industrial Microbiology & Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Bill and Melinda Gates Foundation","keywords":"Heterologous expression; Heterologous; Biology; Computational biology; Microbiology; Biochemistry; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.000987445,0.0008689848,0.004704796,0.00201332,0.00008439333,0.00003776868,0.0009553526,0.005445837,0.00004981743],"category_scores_gemma":[0.003788971,0.00052715,0.0008911019,0.001229865,0.001121882,0.0002065164,0.0004148567,0.006020717,0.00005280826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004948681,"about_ca_system_score_gemma":0.001166108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002039496,"about_ca_topic_score_gemma":0.00001209427,"domain_scores_codex":[0.9948408,0.0006381415,0.002604238,0.0009444896,0.000121249,0.0008511029],"domain_scores_gemma":[0.9958863,0.0003633316,0.002480683,0.0007927521,0.000378297,0.00009868751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001359346,0.0006145274,0.00003452944,0.002097111,0.0009436944,0.0007474053,0.00003202342,5.926106e-8,0.4456582,0.000007018433,0.02131148,0.5271946],"study_design_scores_gemma":[0.001567152,0.001659577,0.000002023349,0.01211597,0.0007786462,0.01410706,0.00004102266,5.127891e-8,0.08318958,0.000008397174,0.8860886,0.0004419377],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05773671,0.9338949,7.128786e-7,0.003037608,0.003840263,0.001209845,0.0002132642,0.00005911419,0.000007616785],"genre_scores_gemma":[0.011006,0.9850203,0.0006036633,0.0001640263,0.002540261,0.000003155769,0.0002464433,0.00007199747,0.000344108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8647771,"threshold_uncertainty_score":0.999718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05038074041508485,"score_gpt":0.2968519202686288,"score_spread":0.246471179853544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}