{"id":"W2901260218","doi":"10.1182/blood-2018-120737","title":"Phase 3 Randomized Study of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Ineligible for Transplant (MAIA)","year":2018,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Lenalidomide; Medicine; Internal medicine; Daratumumab; Transplantation; Multiple myeloma; Melphalan; Surgery; Gastroenterology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002002608,0.001363742,0.002873042,0.0003275912,0.00047163,0.001528898,0.0008947013,0.001508736,0.008775351],"category_scores_gemma":[0.001831019,0.0007474323,0.003063082,0.0003553688,0.001076202,0.001087269,0.0005417492,0.004234323,0.001172839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001199544,"about_ca_system_score_gemma":0.001636704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009971182,"about_ca_topic_score_gemma":0.002877279,"domain_scores_codex":[0.9993055,0.0003358581,0.0000352109,0.0001686809,0.00004855793,0.0001061188],"domain_scores_gemma":[0.9987645,0.0002941243,0.0002714343,0.00009859655,0.00008991995,0.000481471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9767194,0.009560436,0.0008313348,0.0002995681,0.001246395,0.00004304359,0.00004476662,0.0002922724,0.001391881,0.0001204415,0.0007583869,0.008692134],"study_design_scores_gemma":[0.9016748,0.09427363,0.001792898,0.00003014545,0.0005538293,0.00003873124,0.00002416533,0.0003753386,0.0002157264,0.0002458814,0.0007578462,0.00001712985],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790933,0.005476631,0.0008234226,0.001186857,0.001199727,0.008217987,0.001399107,0.0001139985,0.002489017],"genre_scores_gemma":[0.9797809,0.002077763,0.002122963,0.002113092,0.0004721314,0.008101529,0.001529993,0.00002628465,0.003775346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008775351,"threshold_uncertainty_score":0.02935648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02964644555299936,"score_gpt":0.3113519878671562,"score_spread":0.2817055423141568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}