{"id":"W2901348617","doi":"10.3390/cells7110216","title":"Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents","year":2018,"lang":"en","type":"article","venue":"Cells","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Narodowe Centrum Nauki","keywords":"Colchicine; Cytotoxicity; Chemistry; Tubulin; In vitro; Cisplatin; Doxorubicin; Docking (animal); In silico; Potency; Stereochemistry; Pharmacology; Biochemistry; Biology; Microtubule; Cell biology; Chemotherapy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004749934,0.0003887987,0.0003181045,0.0001720842,0.0001219759,0.0001731339,0.0001849198,0.0002042103,0.00141931],"category_scores_gemma":[0.00009915302,0.00010346,0.0001742497,0.0001927131,0.0001034759,0.0001279671,0.0001108588,0.0003135785,0.0002861723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064385,"about_ca_system_score_gemma":0.0001747323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008561633,"about_ca_topic_score_gemma":0.002482682,"domain_scores_codex":[0.9999492,0.000007672884,0.000005142721,0.00001004958,0.00001527267,0.00001262792],"domain_scores_gemma":[0.9999435,0.000004783702,0.00001673251,0.000003956244,0.00001229452,0.00001883786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001542326,0.00003286367,0.00009821222,0.0001499473,0.00001869119,0.0001519017,0.0000167962,0.000549315,0.9936445,0.00009359249,0.0001568661,0.004933096],"study_design_scores_gemma":[0.0000392175,0.001122152,0.001366647,0.00001000621,0.00004058877,0.0003150398,0.00001726473,0.0007259355,0.9908085,0.00002294611,0.005518036,0.00001356255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801808,0.006981642,0.004786296,0.000131239,0.0001089993,0.0001928376,0.0008856055,0.0001432812,0.006589288],"genre_scores_gemma":[0.9859961,0.003436759,0.006550924,0.00007170127,0.00001766405,0.00007050917,0.0006988214,0.00002681307,0.003130834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141931,"threshold_uncertainty_score":0.004748046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1010883015542269,"score_gpt":0.3247058993797022,"score_spread":0.2236175978254752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}