{"id":"W2901348617","doi":"10.3390/cells7110216","title":"Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents","year":2018,"lang":"en","type":"article","venue":"Cells","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Narodowe Centrum Nauki","keywords":"Colchicine; Cytotoxicity; Chemistry; Tubulin; In vitro; Cisplatin; Doxorubicin; Docking (animal); In silico; Potency; Stereochemistry; Pharmacology; Biochemistry; Biology; Microtubule; Cell biology; Chemotherapy; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007119281,0.0001430079,0.0002888852,0.00002206761,0.00008759662,0.00001337359,0.0001166338,0.0001506494,0.001566677],"category_scores_gemma":[0.001386052,0.00009327427,0.00006108073,0.00007682497,0.0002892792,0.00003451404,0.00007797658,0.00007776789,0.00001123452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003424652,"about_ca_system_score_gemma":0.00002679354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003543752,"about_ca_topic_score_gemma":0.000001353089,"domain_scores_codex":[0.9988937,0.00008265889,0.0002599017,0.0003269403,0.0002463793,0.0001903579],"domain_scores_gemma":[0.9989609,0.0004751362,0.0001727857,0.0001481331,0.000179887,0.000063164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001081278,0.0002724525,0.002852391,0.00002422143,0.00003977061,4.540387e-7,0.0000621889,0.000004031772,0.9795704,0.00003351294,0.00006233485,0.01697012],"study_design_scores_gemma":[0.0005003542,0.00007957648,0.01831898,0.00005818356,0.00005782291,0.000001248169,0.0001391285,0.003452076,0.9768225,0.0001579302,0.0002801837,0.0001320135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991865,0.000149448,0.0001252487,0.0001089477,0.00006988965,0.0001215303,0.0000288575,0.00002310304,0.007508003],"genre_scores_gemma":[0.9990461,0.00009638938,0.0005278398,0.00006324379,0.0001746186,0.00001893075,0.000005684576,0.000006975778,0.00006017436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01683811,"threshold_uncertainty_score":0.999346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1010883015542269,"score_gpt":0.3247058993797022,"score_spread":0.2236175978254752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}