{"id":"W2901349083","doi":"10.4049/jimmunol.1500497","title":"Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Yale University; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Germinal center; B cell; Biology; Cell biology; Cytokine; Interleukin 4; T cell; Immunology; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046602,0.0003696296,0.0001984381,0.0003339616,0.0001958528,0.0003584537,0.0001916976,0.0003449563,0.0008158303],"category_scores_gemma":[0.000143352,0.000174465,0.0001945505,0.00009035024,0.0002942129,0.0002722626,0.0003547271,0.0005474493,0.0002709197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002413821,"about_ca_system_score_gemma":0.0002826578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002213123,"about_ca_topic_score_gemma":0.0005004382,"domain_scores_codex":[0.9997465,0.00006284346,0.00002206337,0.00003295996,0.00006068315,0.00007502871],"domain_scores_gemma":[0.9997801,0.00002933693,0.00006321108,0.0000309539,0.00002464812,0.00007176416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000160388,0.0000135473,0.0004566932,0.00001801063,0.000001868637,0.00005758972,0.00001164762,0.00004562887,0.9983978,0.0001294787,0.000006830315,0.0007004572],"study_design_scores_gemma":[0.00002151702,0.0004017179,0.008650548,0.000008133795,0.00001797361,0.0003122146,0.00006026769,0.0006568919,0.9880646,0.0001506351,0.001651639,0.000003761888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953569,0.002060582,0.001369562,0.00003901,0.00001429973,0.0000165889,0.00009866279,0.00003642,0.001007865],"genre_scores_gemma":[0.9972367,0.0003764307,0.001339857,0.00001806559,0.000009025599,0.00001854934,0.00009231889,0.000006648056,0.0009024016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008158303,"threshold_uncertainty_score":0.002729237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161513368013449,"score_gpt":0.2403743229714466,"score_spread":0.2287591892913122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}